Neoadjuvant therapy remodels the pancreatic cancer microenvironment via depletion of pro-tumorigenic immune cells.

CONCLUSIONS: NeoTx is not only cytotoxic, but has pleiotropic, beneficial effects on all cellular and non-cellular components of PCa. Combinational approaches including immunotherapy may unleash long-term and more effective anti-tumor responses and improve prognosis of PCa.
PMID: 31585935 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - October 3, 2019 Category: Cancer & Oncology Authors: Mota Reyes C, Teller S, Muckenhuber A, Konukiewitz B, Safak O, Weichert W, Friess H, Ceyhan GO, Demir IE Tags: Clin Cancer Res Source Type: research