Risk of Zika microcephaly correlates with features of maternal antibodies

We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015–2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Infectious Disease and Host Defense Articles Source Type: research

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Zika virus (ZIKV) infection during pregnancy has severe consequences on the new-born. The World Health Organization declared the Zika outbreak to be a Public Health Emergency of International Concern (PHEIC) i...
Source: BMC Women's Health - Category: OBGYN Authors: Tags: Research article Source Type: research
[Mental health from the perspective of women affected by the Zika virus: an ethnographic study in Pará State, Brazil]. Cad Saude Publica. 2020;36(8):e00100019 Authors: Silva DAD, Silva ÉQ Abstract The current study reflects on the Zika virus outbreak that struck the Brazilian population, with both physical and emotional aspects for all those affected. There is a particular group that has to deal on a daily basis with all the difficulties imposed by this new reality: women. The basic assumption of this approach is the need to learn about, understand, and grasp these biopsychosocial issues...
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
CONCLUSION: Some pregnant women are accepting of participation in vaccine research during infectious disease outbreaks. Incorporating their priorities into trial design may facilitate their participation and generation of evidence for this important population. PMID: 32893036 [PubMed - as supplied by publisher]
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
The Zika Contraception Access Network (Z-CAN) was a short-term emergency response intervention that used contraception to prevent unintended pregnancy to reduce Zika-related adverse birth outcomes during the 2016-2017 Zika virus outbreak in Puerto Rico. Strategies and safeguards were developed to ensure women who chose long-acting reversible contraception (LARC) had access to no-cost removal, if desired, after Z-CAN ended.Study DesignWe assessed the number of women who chose LARC at their initial Z-CAN visit who filed complaints regarding challenges with LARC removal within 30-months after the Z-CAN program ended.
Source: Contraception - Category: OBGYN Authors: Source Type: research
ra RJ, Soriano A, Bentes GA, de Oliveira Bottino F, Salvador Castro Faria SB, Nudelman RF, Lopes CAA, Perea JAS, Sarges K, Andrade MCR, Motta MCVA, Freire MS, Souza TML, Schmidt-Chanasit J, Pinto MA Abstract The outbreaks of Zika virus (ZIKV) infection in Brazil, 2015-2016, were associated with severe congenital malformations. Our translational study aimed to test the efficacy of the antiviral agent sofosbuvir (SOF) against vertical transmission of ZIKV and the associated congenital syndrome (CZS), using a rhesus monkey model. Eight pregnant macaques were successfully infected during the organogenesis phase with a...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Abstract A sporadic but autochthonous dengue fever outbreak occurred in Tokyo in 2014, although the dengue virus is not in general circulation in Japan. Another lethal infectious disease, known as severe fever with thrombocytopenia syndrome (SFTS), was discovered to be endemic to Japan in January 2013. More than 400 patients with SFTS have been reported so far. The fatality rate of SFTS is approximately 30%. Also in 2014, a large outbreak of mosquito-borne Zika virus infections occurred in the South and Central parts of the American continent. Transplacental infection of a fetus with Zika virus occurs when pregnan...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Tags: Yakugaku Zasshi Source Type: research
In the year 2015 a temporal relation was observed between the increase in notifications of microcephaly and the outbreak of Zika virus (ZIKV) becoming a significant public health problem in Brazil (Nunes et al. 2016). This increase in cases of microcephaly favored the development of diagnostic guidelines with more accurate neonatal screening parameters to better evaluate infants exposed to maternal ZIKV infection. Changes in the fetal Central Nervous System (CNS), as well as in several other systems, have given rise to what is known as Congenital Zika Virus Syndrome (CZS) (Brito 2015; Schuler-Faccini et al.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Before the 2015 Zika virus (ZIKV) outbreak in Latin America, little attention had been paid to ZIKV, first discovered in 1947, mainly because of its mild symptoms and short duration, which were similar to other arboviral diseases. Now, however, an association between ZIKV infection and neurologic outcomes such as Guillain-Barr é Syndrome (GBS) in infected adults and central nervous system malformation of fetuses in infected pregnant women has been established.1 A recent systematic review found that microcephaly is the most commonly reported adverse outcome of ZIKV infection, followed by GBS.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Conclusions: More detailed knowledge of ZIKV infection in children allows the pediatrician to diagnose earlier, implement the correct treatment, monitor warnings signs for the most severe forms, and especially establish effective preventive measures. ABBREVIATIONS: CDC, Centers for Disease Control; CZS, congenital Zika syndrome; DEET, N, N-diethyl-3-methylbenzamide; GBS, Guillain-Barré syndrome; PRNT, plaque reduction neutralisation test; RNA, ribonucleic acid; RT-PCR, reverse transcriptase polymerase chain reaction; STX, saxitoxin; ZIKV, Zika virus. PMID: 32576082 [PubMed - as supplied by publisher]
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
ConclusionsThe WHO Framework encapsulated important infrastructure and process factors relevant to the Florida Zika response as well as future epidemics. In this context, similarities, differences, and implications for the Coronavirus COVID-19 pandemic response are discussed.
Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
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