When alpha meets beta, mast cells get hyper

The evolutionary conservation of the catalytically inactive α-tryptase gene has remained a mystery. In this issue of JEM, Le et al. (2019. J. Exp. Med. https://doi.org/10.1084/jem.20190701) unveil the existence of a novel but natural tryptase, heteromeric α/β-tryptase, a critical mediator of α-tryptase–associated diseases.
Source: The Journal of Experimental Medicine - Category: Internal Medicine Authors: Tags: Infectious Disease and Host Defense, Human Disease Genetics Insights Source Type: research