Nobel Prize in Medicine Awarded to 3 Scientists for Oxygen Research

STOCKHOLM — The 2019 Nobel Prize for Physiology or Medicine has been awarded to scientists William G. Kaelin, Jr, Peter J. Ratcliffe and Gregg L. Semenza. They received the award jointly for their discoveries of “how cells sense and adapt to oxygen availability,” the Nobel Committee announced Monday. Two of the scientists, Kaelin and Semenza, are U.S.-based, at Harvard University and Johns Hopkins respectively. The other scientist, Ratcliffe, is based at the Francis Crick Institute in London. BREAKING NEWS:The 2019 #NobelPrize in Physiology or Medicine has been awarded jointly to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability.” — The Nobel Prize (@NobelPrize) October 7, 2019 It is the 110th prize in the category that has been awarded since 1901. The Karolinska Institutet said in a statement the trio should share equally the 9 million kronor ($918,000) cash award. The discoveries made by the three men “have fundamental importance for physiology and have paved the way for promising new strategies to fight anemia, cancer and many other diseases,” the Committee said.
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized nobel prize Source Type: news

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This study was designed to evaluate the efficacy and safety of apatinib, a novel tyrosine kinase inhibitor targeting tumor angiogenesis, as second-line treatment in recurrent or advanced cervical cancer patients. Twenty patients who failed cisplatin/paclitaxel ± bevacizumab treatment received a 4-week cycle of apatinib, with a daily dosage of 500 mg or 250 mg. The follow-up period ranged from 5.9 to 21.3 months (median, 14.0 months). None of the patients achieved a complete response (CR). Nevertheless, a partial response (PR), stable disease (SD) an d progressive disease (PD) were observed i...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
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Source: Translational Research - Category: Research Authors: Source Type: research
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Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
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Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
Conditions:   Aplastic Anemia;   Paroxysmal Nocturnal Hemoglobinuria Interventions:   Other: symptom questionnaire;   Other: recording of vital signs;   Other: European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ)-C30 questionnaire;   Other: interview Sponsors:   University Hospital, Basel, Switzerland;   ProPatient foundation of the University Hospital Basel;   Novartis Not yet recruiting
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Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
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Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
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Source: Oncology Reviews - Category: Cancer & Oncology Source Type: research
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