Endometriosis: The condition that can take over seven years to diagnose
Three women out of 13,500 who took part in BBC research, explain how the condition affects them.
Publication date: Available online 11 October 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Philippe R. Koninckx, Anastasia Ussia, Muna Tahlak, Arnaud Wattiez
AbstractThe aim of this review is to evaluate the effectiveness and safety of uterine manipulators in facilitating total laparoscopic hysterectomy (TLH). A literature search in MEDLINE, EMBASE, Cochrane Library, UpToDate, SpringerLink, ClinicalKey and Elsevier ScienceDirect databases was performed, and articles describing TLH with or without the use of uterine manipulators were retrieved. Complications related to the use of uterine manipulators are numerous, and although uterine manipulator seems to facilitate TLH, the procedure without a uterine manipulator seems to have a comparable safety and effectiveness, although evi...
Authors: Laiz Díez B, García Muñoz-Najar A, Durán Poveda M Abstract Endometriosis is the presence of extra-uterine endometrial tissue and affects 6-10% of fertile women. In 3-37% of the cases it affects the gastrointestinal tract being the ileal location extremely infrequent. Symptoms are nonspecific, debuting as intestinal obstruction in 7-23% of cases. The definitive diagnosis is anatomopathological and the treatment in these cases of acute abdomen is surgery. We attach the present case due to its rarity, it is a young asymptomatic woman who debuts with a picture of intestinal obstruct...
This study aimed to determine whether transcription factor 21 (TCF21) is involved in the development of endometriosis as an upstream regulatory gene of periostin. Formalin-fixed, paraffin-embedded tissue samples (normal endometrium of women without endometriosis, NE; eutopic endometrium of women with endometriosis, EE; ovarian endometriosis, OE; deep infiltrating endometriosis, DIE) and respective cells were analyzed.
Because of the reported association between endometriosis and cardiovascular disease [1, 2], Taskin et al  suggested that endometriosis should be considered a risk factor for atherosclerotic cardiovascular disease requiring specific counselling and prevention . Both are diseases of chronic inflammation with potentially underlying genetic similarities. The premature menopause in endometriosis might be a co-factor increasing the cardiovascular risk. It surprises that in these excellent articles the methodological problems and potential biases are not discussed adequately.
ConclusionThe circulating non-coding RNAs have great ability of diagnosing endometriosis as non-invasive markers which were performed robustly and accurately.
ConclusionsThese findings suggest that CTHRC1 may be partly responsible for the development and progression of endometriosis by increasing EESC proliferation, migration and invasion via Wnt/β-catenin pathway, and thus serves as a diagnostic and therapeutic target for endometriosis.
ConclusionThe ultrasonographic evaluation of the type and extension of adenomyosis in the myometrium seems to be important in correlation to the severity of symptoms and infertility.