mGluR5 and Fragile-X Syndrome (FXS)

Conclusions:This study was the first to identify upregulation of mGluR5 density and expression in the prefrontal cortex of FXS patients or carriers compared to an age- and sex-matched control group. This is consistent with several studies in FXS model mice that postulate that the syndromic features of FXS are caused by an upregulated mGluR5 signaling pathway. Although the sample size was relatively small and the results could be secondary to prior medication treatment, these initial findings provide strong rationale for measuring mGluR5 in live patients using PET. Such in-vivo studies could measure mGluR5 in all brain regions; the results could also be correlated with treatment response to mGluR5 negative allosteric modulators.
Source: Neuromics - Category: Neuroscience Tags: ; mGluR Human Cortex Metabotropic glutamate receptor type 5 Western Blot Fragile X mental retardation Metabotropic glutamate receptor; mGluR5 Western Blotting FXS Source Type: news