4.73 from the synapse to brain volume: a comparative study between youth with schizophrenia and patients with anti-n-methyl-d-aspartate (nmda) receptor encephalitis

The N-methyl-d-aspartate receptor (NMDAR) hypofunction model of schizophrenia suggests that dysfunction of these receptors leads to an excess release of glutamate and could explain the brain structural abnormalities characterizing these patients. In NMDAR encephalitis (NMDARE), which holds clinical similarities with schizophrenia, autoantibodies target NMDARs, leading to increased levels of glutamatergic metabolites in brain tissue. No study so far has examined these disorders comparatively.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Source Type: research