5.73 use of prazosin for intrusive symptoms in pediatric ptsd: a proof-of-principle study

Only few studies have investigated pharmacologic treatment for juvenile PTSD. Antiadrenergic agents are an interesting option, because of an autonomic nervous system hyperactivation in PTSD. Prazosin, an α-1 antagonist, has proven its efficacy in an adult population. In the pediatric population, few data support its use for nightmares and sleep disturbances in PTSD. We aim to assess the efficacy and safety of prazosin in a pediatric population.

Source: Journal of the American Academy of Child and Adolescent Psychiatry - September 30, 2019 Category: Psychiatry Authors: Vladimir Ferrafiat, Maryam Soleimani, Boris Chaumette, Audrey Martinez, Adlane Inal, Jean-Marc Guile, Brooks Keeshin, Priscille Gerardin Source Type: research