Medical staffers are experts. But my hospital travails show why they can get it dangerously wrong.

How my repeated ER visits were part of my frustrating experience with a thyroid cancer odyssey.
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news

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We present the case of a patient withBRAF-negative stage IVC anaplastic thyroid cancer (ATC) treated with the anti-PD-1 monoclonal antibody, pembrolizumab, following radiographic progression on chemoradiation. Blood samples were collected prior to and at four time points during treatment with pembrolizumab. Mass cytometry was used to determine expression of relevant biomarkers by peripheral blood mononuclear cells. Faecal samples were collected at baseline and 4  weeks following treatment initiation; taxonomic profiling using 16S ribosomal RNA (rRNA) gene sequencing was performed. Following treatment, a marked ex...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
Conclusion: Our findings, along with other reports, suggest that MKIs is an effective neoadjuvant therapy and should be considered as a therapeutic strategy for unresectable grossly locally invasive thyroid carcinomas.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Condition:   Thyroid Cancer Intervention:   Sponsor:   Royal Marsden NHS Foundation Trust Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This population-based cohort study uses the Health Insurance Review and Assessment database of South Korea to examine the association between adverse pregnancy outcomes and radioactive iodine treatment after thyroidectomy among South Korean women of childbearing age with thyroid cancer.
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
ConclusionOur findings suggest that nevirapine significantly repressed migration and invasion/metastasis in WRO 82 ‐1 cells and tumor xenografts, which may be related to inhibition of IL‐6/STAT3 signaling pathway. It promises great potential as a novel therapy for thyroid cancer, especially for those patients with metastasis.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Authors: Möckelmann N, Betz C Abstract The majority of patients with thyroid cancer have a remarkably good chance of cure in the context of surgical treatment, due to their mostly local tumor spread. However, a small proportion of patients with advanced and metastatic thyroid tumors usually require multimodality treatment. Abstracts from the 2019 American Society of Clinical Oncology (ASCO) Annual Meeting are summarized in this review, to provide insights into current aspects of thyroid carcinoma treatment. In addition to innovations in the treatment of radioiodine-refractory differentiated and medul...
Source: HNO - Category: ENT & OMF Tags: HNO Source Type: research
ari G Abstract Papillary thyroid microcarcinoma (PTMC) is defined by the World Health Organization as papillary cancer measuring 10 mm or less in diameter. Generally, PTMC shows an indolent clinical behavior with a good prognosis, although a minority of PTMC is characterized by an aggressive course. However, efforts to identify this aggressive subset of PTMC after surgery remain inconclusive. Several oncogenic pathways have been identified in thyroid cancer and have been applied translationally to improve prognosis and clinical management. In particular, the BRAFV600E mutation was found more frequently in large, a...
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research
ConclusionActive surveillance for low-risk PTC has shown its safety and feasibility in certain populations. In the future, it is warranted to determine valuable tumor progression predictors and most suitable PTC patients for AS.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Li J, Zhang B, Bai Y, Liu Y, Zhang B, Jin J Abstract Sphingosine kinase 1 (SPHK1), an ATP-dependent protein, has previously been demonstrated to be upregulated in several types of human cancer and to play an important role in tumor development and progression. However, the role of SPHK1 in predicting long-term prognosis in patients with papillary thyroid carcinoma (PTC) remains unclear. The purpose of the present study was to assess the significance of SPHK1 expression and its associations with clinicopathological characteristics and prognostic outcome in patients with PTC. Immunohistochemistry staining wa...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
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