Jejunal wall delivery of insulin via an ingestible capsule in anesthetized swine —A pharmacokinetic and pharmacodynamic study

In conclusion, (a) The bioactivity of RHI was preserved after its delivery into the jejunal wall, (b) the intrajejunal route delivered insulin as rapidly and physiologically as the subcutaneous rou te, and (c) these pharmacokinetic and pharmacodynamic characteristics of RHI after intrajejunal delivery suggest that drugs currently administered parenterally, such as basal insulin, could be successfully delivered into the proximal intestinal wall via the ingestible capsule.

Source: Pharmacology Research and Perspectives - October 2, 2019 Category: Drugs & Pharmacology Authors: Mir Hashim, Radhika Korupolu, Baber Syed, Kyle Horlen, Simret Beraki, Padma Karamchedu, Arvinder K. Dhalla, Rodolphe Ruffy, Mir Imran Tags: ORIGINAL ARTICLE Source Type: research