[Development of Stratified and Personalized Medicine Based on Pharmacogenomic and Pharmacokinetic Analyses].

In this study, we elucidated the effect of CYP4F2 polymorphisms associated with vitamin K metabolism by measuring the blood concentrations of warfarin and vitamin K. Then, to develop precision medicine for asthma and chronic obstructive pulmonary disease (COPD), we analyzed not only clinical symptoms but also pathological biomarkers and genes associated with inflammation. The findings may contribute toward better understanding of the pathological conditions of asthma, COPD, and asthma-COPD overlap.
PMID: 31582608 [PubMed - in process]

Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - October 6, 2019 Category: Drugs & Pharmacology Authors: Hirai K Tags: Yakugaku Zasshi Source Type: research