Current Concepts in the Surgical Management of Non-melanoma Skin Cancers
The surgical management of non-melanoma skin cancers has seen some significant changes over the past 20 years, as a result of developments in three equally important and overlapping specialties that deal with this specific pathology: plastic and reconstructive surgery, surgical oncology and dermatological surgery. Better understanding of vascular and particularly microvascular anatomy, coupled with technological advances in operating microscopes, microsurgical instrumentation and preoperative planning via advanced imaging, allows functional and aesthetic restoration of any radical oncological skin and soft-tissue surgery defect from head to toe.
In 2012, Eleni Linos, professor of dermatology at Stanford university, published a systematic review and meta-analysis of the link between non-melanoma cancer and sun-beds. That bit of pretty standard research, and a particular rapid response to it, has kicked of years of work - and in this podcast I talk to Eleni and her colleagues Stanton...
Authors: Samaka RM, Basha MA, Mansour E Abstract Purpose: To evaluate the role of autophagy related gene 7 (ATG7) in non-melanoma skin cancer. Subjects and Methods: This retrospective and prospective case-control study was performed on 104 patients with non-melanoma skin cancer (NMSC) in addition to 20 apparently healthy subjects matched for age and sex as a control group. Multiple skin biopsies were taken for immunohistochemical evaluation of ATG7 expression. Results: Both epithelial and stromal ATG7 were expressed in all participants while all patients showed nucleocytoplasmic localization and controls sh...
With funding from the National Cancer Institute, a team of researchers at the University of Arizona Cancer Center is seeking effective preventive and therapeutic strategies to reduce the risk of non-melanoma skin cancer, like squamous cell carcinoma of the skin.
(University of Arizona Health Sciences) Skin cancer is the most common malignancy worldwide, and one in three new cancers diagnosed is a form of skin cancer. In response, a team of researchers at the University of Arizona Cancer Center is developing new strategies to prevent and reduce the risk of squamous cell carcinoma, the second most-common form of non-melanoma skin cancer.
(Wiley) Higher levels of mercury in the blood were linked with a higher prevalence of non-melanoma skin cancer, the most common human malignancy, in a study published in the British Journal of Dermatology.
ConclusionIn patients with PsA, tofacitinib had a safety profile similar to that of other systemic therapies in real-world settings, except for the risk of HZ, a known risk of tofacitinib.Trial RegistrationClinicalTrials.gov: NCT01877668; NCT01882439; NCT01976364.
CONCLUSION: Based on the experiment, the accuracy of the developed approach is 90%, which reflects its reliability. PMID: 31989893 [PubMed - in process]
ConclusionsThe perceived aesthetic appreciation of patients does not seem to be significantly influenced by facial skin cancer SE or MMS surgery in this 3-month follow-up study.Level of evidence: Not ratable.
Angiosarcomas are malignant neoplasms arising from endothelial cells. Cutaneous angiosarcoma is the most common form, typically occurring in the setting of chronic lymphedema or previous radiation. The head and neck are the most common locations for cutaneous angiosarcoma, with rare occurrence on the trunk and extremities. Herein, we present a case of angiosarcoma on the lower extremity in an elderly man. This 71-year-old man presented with a two-year history of red-yellow discoloration of the left lower leg with subsequent development of black nodules over the past several months prior to presentation. He denied any itchi...
We discuss a woman with a history of non-melanoma skin cancer who presented with a new erythematous macule on her right temple. On examination with Wood lamp the well-demarcated macule fluoresced pink making neoplasm unlikely. Further history and physical examination suggested an inadvertent ink stain and the patient was spared a biopsy highlighting the importance of eliciting a good history and performing a detailed physical examination with additional tools such as a Wood lamp when necessary.