NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-inflammatory Response Syndromes in Mice With Acute Pancreatitis

Pancreatitis starts with primarily sterile local inflammation that induces systemic inflammatory response syndrome (SIRS) followed by compensatory anti-inflammatory response syndrome (CARS). We investigated mechanisms of these processes in mice and human serum.

Source: Gastroenterology - October 4, 2019 Category: Gastroenterology Authors: M. Sendler, C. van den Brandt, J. Glaubitz, A. Wilden, J. Golchert, F.U. Weiss, G. Homuth, L.L. De Freitas Chama, N. Mishra, U.M. Mahajan, L. Bossaller, U. V ölker, B.M. Bröker, J. Mayerle, M.M. Lerch Source Type: research