Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?

This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ  = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms—Clinician rated scale (IDS-C). Their relationship with several cognitive domains was tested using separate A NCOVAs. A three-way between-groups ANOVA was conducted to test if the relationship with cognitive impairments varies between different sleep disturbances. These analyses revealed significantly poorer processing speed and inhibition in those with any sleep disturbance versus those without, also after adjusting for several covariates. The relationship between sleep disturbances and cognition was similar across SCZ and BD, and there were significant effects of insomnia and hypersomnia on both processing speed and inhibition. No association between sleep disturbances and cognition was found in HC. Sleep disturbances contribute to cognitive impairments in psychotic disorders. Processing speed and inhibition is poorer in patients with sleep disturbances. Impairments in these domai...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research

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Publication date: December 2019Source: Results in Physics, Volume 15Author(s): Mohammad Karbalaei, Daryoosh Dideban, Hadi HeidariAbstractThis paper presents the electrical characteristics of a short channel Silicon on Insulator (SOI) transistor with a graphene layer. The graphene sheet is used at the bottom of the channel close to the source side and a proportionally heavily p-type retrograde doping implanted in nearly middle of the channel. To increase the gate electrostatic control over the channel we incorporated a high-K material i.e. HfO2 as the gate oxide insulator. Due to Graphene growth and Retrograde Doping in the...
Source: Results in Physics - Category: Physics Source Type: research
Publication date: Available online 18 November 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Z Malihi, Z Wu, CMM Lawes, J Sluyter, D Waayer, L Toop, K-T Khaw, CA Camargo, R ScraggABSTRACTWith increasing numbers of randomized controlled trials (RCTs) investigating potential health events of vitamin D supplementation, a better understanding is required of the risk factors for adverse events and for study withdrawals. This analysis aimed to identify baseline risk factors of reporting an adverse event in a multi-year randomized double-blinded placebo-controlled trial of vitamin D supplementati...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
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Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
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Source: Quality of Life Research - Category: Health Management Source Type: research
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Source: Quality of Life Research - Category: Health Management Source Type: research
ConclusionsThese results suggest that O/P ratio can be related to current and future engagement in pro-environmental behavior and improvement in subjective well-being which could lead to an environmentally sustainable society with enhanced quality of life.
Source: Quality of Life Research - Category: Health Management Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
BACKGROUND: Various associations between monthly Google search volumes (MGSVs) and monthly suicide rates (MSRs) have been reported. However, these studies often analyzed a limited number of search terms using suboptimal statistical methods. While controlli...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Media, Marketing, and Internet Issues Source Type: news
This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms-Clinician rated scale (IDS-C). ...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Conclusions: Sleep patterns in children and adolescents were related to the psychiatric diagnosis of their parent(s). Future follow-up of these results may clarify the relations between early sleep differences and the risk of developing mood disorders in individuals at high familial risk.IntroductionSleep disturbances are core symptoms of mood disorders including major depressive disorder and bipolar disorder (1). Additionally, sleep problems have been associated with more severe symptoms, greater functional impairment, and increased risk for relapse among individuals with mood disorders (2). Over 40% of children and youth...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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