Three unprecedented biphenyl derivatives bearing C6-C3 carbon skeleton from the bark of Magnolia officinalis var. biloba

Publication date: Available online 4 October 2019Source: Chinese Chemical LettersAuthor(s): Chuan Li, Kailing Xu, Chuangjun Li, Jie Ma, Xiaoliang Wang, Dongming ZhangAbstract(±)-Magoilgomer A [(±)-1] and magoilgomer B (2) were identified from the bark of Magnolia officinalis var. biloba. (+)-1 and (−)-1 were a pair of novel biphenyl derivatives featuring three C6-C3 subunits. 2 was an unprecedented adduct containing magnolol and honokiol. These three oligomers possessed new parallel mode which should be biosynthesized from the coupling of three or four C6-C3 subunits. The structures of (±)-1 and 2 were elucidated based on the spectroscopic data analyses and electronic circular dichroism (ECD) calculations. 2 exhibited neuroprotective effects of oxygen glucose deprivation-induced SK-N-SH cell injury.Graphical abstractThree novel compounds, (±)-magoilgomers A [(±)-1] and B (2), were identified from the bark of Magnolia officinalis var. biloba.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research