Off-label studies on tofacitinib in dermatology: a review.

Conclusion: While tofacitinib has a wide array of immunoregulatory properties, making it a possible candidate for treating many dermatologic conditions refractory to other treatments, further testing is needed to better characterize its efficacy and utility moving forward, as well as its safety and adverse effect profile. PMID: 31581859 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research

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Authors: Moniaga CS, Tominaga M, Takamori K Abstract Chronic itch is a burdensome clinical problem that often accompanies pathological dry skin-based conditions, such as atopic dermatitis, and systemic disorders, such as kidney diseases, with an unclear pathomechanism and treatments. One of the basic mouse models to investigate mechanisms of itch associated with dry skin is a mixture of acetone and ether followed by water. Animal studies using the acetone and ether followed by water model have revealed that many mediators and receptors, e.g. mas-related G protein-coupled receptor family, transient receptor potentia...
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
We report a patient with relapsing-remitting multiple sclerosis, who developed rheumatoid arthritis after exposure to natalizumab. While some multiple sclerosis therapies are known to unmask autoimmune conditions, natalizumab is rarely implicated as a cause of alternative autoimmunity. This case illustrates an unusual clinical scenario which may support recent scientific work suggesting that when natalizumab blocks T helper 1 cells from entering the central nervous system, T helper 17 cells may continue to migrate into immune-privileged spaces and cause pathologic inflammation.Brief Background: Multiple sclerosis (MS) pati...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Jorge Zamora-Quezada, MD, falsely diagnosed patients has having rheumatoid arthritis, treated them with toxic drugs, and falsified medical records to mislead a federal investigation.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Rheumatology News Source Type: news
Publication date: Available online 16 January 2020Source: Best Practice &Research Clinical GastroenterologyAuthor(s): Amihai Rottenstreich, Ariella Bar-Gil ShitritAbstractInflammatory bowel diseases (IBD) are commonly diagnosed in women of childbearing age. As such, pregnancy is often encountered in this subset of patients. Management of pregnancy in IBD patients poses numerous challenges as ensuring the safety of the mother and the fetus is required. Disease remission prior to pregnancy is a key determinant of both the course of IBD throughout gestation and pregnancy outcome. Thus, adequate preconception care is of pa...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Publication date: Available online 15 January 2020Source: Canadian Journal of CardiologyAuthor(s): Ming-Jer Hsieh, Cheng-Hung Lee, Ming-Lung Tsai, Chang-Fu Kao, Wen-Ching Lan, Yu-Tung Huang, Wen-Yi Tseng, Ming-Shien Wen, Shang-Hung ChangAbstractBackgroundTumor necrosis factor inhibitors (TNFi) improve joints outcomes and reduce cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). However, 20-45% of RA patients are TNFi poor responders and have a significantly higher risk of CV events. In these TNFi non-responders, the use of second-line biological agents to improve synovial outcomes is supported by clinical...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
ConclusionsGeneral-population infants introduced to peanut after age 12 months were more likely to have sensitization and probable clinical allergy to peanut at 3 years.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Authors: Otsubo Y, Nishijo T, Mizumachi H, Saito K, Miyazawa M, Sakaguchi H Abstract Skin sensitization is a key adverse effect to be addressed during hazard identification and risk assessment of chemicals, because it is the first step in the development of allergic contact dermatitis. Multiple non-animal testing strategies incorporating in vitro tests and in silico tools have achieved good predictivities when compared with murine local lymph node assay (LLNA). The binary test battery of KeratinoSensTM and h-CLAT could be used to classify non-sensitizers as the first part of bottom-up approach. However, the quantit...
Source: Journal of Toxicological Sciences - Category: Toxicology Tags: J Toxicol Sci Source Type: research
Authors: Abuaisha M, El Masri R, Itani H, Antoun J Abstract Objectives: There are no evidence-based recommendations to screen for iron deficiency in non-anemic patients, even though symptoms may be present. The aim of this study is to measure the prevalence of iron deficiency (ID) without anemia in the general population aged 18-50 presenting to primary care along with the incidence and time to develop anemia in the iron-deficient population.Methods: A single-center retrospective chart review of patients who presented to family medicine clinics between June 2010 and March 2018 at the American University of Beirut M...
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
Robin shared her husband’s life-altering Wheat Belly experience: “I wanted to encourage those just starting out and getting through the difficult detox. If you are rethinking your decision, know that you are doing the best thing you could ever do for yourself and your family. “This is a picture of my husband, Kirk. He is 50 and had plans of having to go on disability this year due to the extreme pain in every joint in his body. Walking was extremely difficult. He works 10 hours a day in lawncare. We thought he had lupus or rheumatoid arthritis. Plus he suffered horrible gout attacks that would put him dow...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Open autoimmune gluten-free grain-free Inflammation Weight Loss wheat belly Source Type: blogs
Journal of Clinical Sleep Medicine, Ahead of Print.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Authors: Source Type: research
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