Direct and indirect suppression of Scn5a gene expression mediates cardiac Na+ channel inhibition by Wnt signalling

ConclusionsWnt signalling inhibits Na+ channel by direct and indirect (via Tbx3) suppression of Scn5a transcription. Strategies to block TCF4 binding to Tbx3 and Scn5a promoters would represent novel strategies for cardiac-specific inhibition of Wnt pathway to rescue INa and prevent sudden cardiac deaths.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research