Insights From Atrial Fibrillation Genomics: From Bedside to Bench and Back Again
From the bedside of patients contributing samples to large genome-wide association studies for atrial fibrillation (AF), over 100 AF risk loci have been identified. The top locus is near a gene implicated in pulmonary vein formation; the ostia of the pulmonary veins harbor initiating triggers of AF, and isolation of these areas is the cornerstone of ablation therapies for AF. Transcriptomic studies suggest that AF is associated with impaired or overwhelmed responses to cell stress. A dual risk model proposes that in genetically-susceptible individuals, inadequate transcriptional responses to stress predispose to AF in later life. Drugs targeting metabolic, oxidative, or protein handling stress may be novel upstream agents to bring back to the bedside for study in the prevention of AF.
Conditions: Leukemia, Chronic Lymphatic; Mantle Cell Lymphoma Intervention: Sponsor: European Georges Pompidou Hospital Recruiting
Review the various types of antiarrhythmic agents used in the treatment of atrial fibrillation in this primer. How should the selection of an appropriate drug be made?U.S. Pharmacist
AbstractDual antiplatelet therapy (DAPT) duration in patients undergoing percutaneous coronary intervention (PCI) has long been considered a matter of controversy. Complex-PCI (C-PCI) is considered to be associated with an increased ischemic risk that tends to be greater with progressively higher procedural complexity. Thus, with a view to balance ischemic versus bleeding risks, high complexity of PCI intuitively represents an advocate of prolonged DAPT duration. However, the optimal DAPT strategy in this high ischemic risk subset of patients remains unclear, a fact that is exacerbated by the absence of a universal definit...
Conditions: Persistent Atrial Fibrillation; Catheter Ablation; Pulmonary Vein Isolation; Posterior Wall Isolation Interventions: Procedure: Pulmonary vein isolation; Procedure: Left posterior wall isolation Sponsor: Institute for Clinical Effectiveness, Japan Not yet recruiting
Genetic testing for clopidogrel resistance and a new strategy for atrial fibrillation ablation are among the highlights from the virtual ACC scientific sessions.Medscape Medical News
Conclusions: In HFpEF patients associated with AF, beta-blocker treatment is associated with significantly lower all-cause mortality, but it increased the risk of rehospitalization due to heart failure. PMID: 32454997 [PubMed]
Conclusions: AD and CVD are frequently associated. Further studies are needed in order to understand the effect of CVD and its risk factors on AD in order to better comprehend the effects of subclinical and clinical CVD on the brain. Finally, we need to clarify the impact of the underlying hypothesized mechanisms of this association and to investigate gender issues. PMID: 32454996 [PubMed]
Physicians and clinicians are facing the unique challenge of practicing social distancing with their patients during the COVID-19 pandemic. It seems almost impossible because the practice of healthcare is so hands-on. However, Eko Health is hoping to overcome this challenge by marrying its technology with telemedicine. Last week, the digital health company launched Eko Telehealth, an artificial intelligence-powered telemedicine platform geared toward cardiac exams. âAs we think of the future of healthcare, the fact the clinician and the patient arenât in the same room shouldnâ...
In this study, we investigate the predictors for paroxysmal AF.MethodsSubjects were consecutive paroxysmal AF patients who underwent high-dose isoproterenol provocation after PV isolation in the first session. The PV group (n = 102) and non-PV group (n = 222) were defined as the patients with and without non-PV ablation, respectively. Non-PV ablation was performed when frequent repetitive premature atrial contractions or triggered AF occurred spontaneously or by isoproterenol provocation. Predictors of non-PV origin in paroxysmal AF patients were examined using clinical characteristics and preop...