Gamma Delta T Cell Function in Ruminants

Gamma delta ( γδ) T cells constitute a major lymphocyte population in peripheral blood and epithelial surfaces. They play nonredundant roles in host defense against diverse pathogens. Although γδ T cells share functional features with other cells of the immune system, their distinct methods of antigen recog nition, rapid response, and tissue tropism make them a unique effector population. This review considers the current state of our knowledge on γδ T cell biology in ruminants and the important roles played by this nonconventional T cell population in protection against several infectious diseases of veterinary and zoonotic importance.
Source: Veterinary Clinics of North America: Food Animal Practice - Category: Veterinary Research Authors: Source Type: research