Ethics and entrapment: understanding counterterrorism stings - Field A.

This article examines domestic counterterrorism sting operations in the USA. It considers why critics consider these operations unethical and illegitimate. In particular, it looks at claims that counterterrorism sting operations have entrapped innocent peo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Jurisprudence, Laws, Legislation, Policies, Rules Source Type: news

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ConclusionFor the first time, we demonstrate that HHV-6A, HHV-6B, and HHV-7 infections have a differential impact on intracellular DNA sensors. HHV-6B and HHV-7 mainly lead to the active control of in vivo viral spreading by pro-inflammatory cytokine secretion via TLR9. HHV-6A infected NK cells conversely induced STING/STAT6 pathway, as a mechanism of anti-viral activation, but they were characterized by a Th2 type response and a non-cytotoxic profile, suggesting a potential novel mechanism of HHV-6A-mediated immunosuppression.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract The generation of DNA double-strand breaks has historically been taught as the mechanism through which radiotherapy kills cancer cells. Recently, radiation-induced cytosolic DNA release and activation of the cGAS/STING pathway, with ensuing induction of interferon secretion and immune activation, have been recognized as important mechanisms for radiation-mediated anti-tumor efficacy. Here we demonstrate that radiation-induced activation of endogenous retroviruses (ERVs) also plays a major role in regulating the anti-tumor immune response during irradiation. Radiation-induced ERV-associated dsRNA transcrip...
Source: Radiation Research - Category: Physics Authors: Tags: Radiat Res Source Type: research
Contributors : Priscilla Turelli ; Delphine GrunSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapienshiPSC were treated or not with STING inhibitor, transduced with KD or control lentivectors and differentiated in induced neurons.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Intranasal mucosal vaccines are an attractive approach to induce protective mucosal immune responses. Activation of lung antigen presenting cells (APCs), a phenotypically and functionally heterogeneous cell population located at distinct mucosal sites, may be key to the immunogenicity of such vaccines. Understanding responsiveness of newborn lung APCs to adjuvants may the inform design of efficacious intranasal vaccines for early life, when most infections occur. Here, we characterized and phenotyped APCs from neonatal (7 days of life) and adult (6–8 weeks of age) mice. Neonatal mice demonstrated a relatively high ab...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Zebrafish NIK Mediates IFN Induction by Regulating Activation of IRF3 and NF-κB. J Immunol. 2020 Feb 17;: Authors: Chen B, Li C, Yao J, Shi L, Liu W, Wang F, Huo S, Zhang Y, Lu Y, Ashraf U, Ye J, Liu X Abstract Type I IFN mediates the innate immune system to provide defense against viral infections. NF-κB-inducing kinase (NIK) potentiates the basal activation of endogenous STING, which facilitates the recruitment of TBK1 with the ectopically expressed IRF3 to induce IFN production. Moreover, NIK phosphorylates IKKα and confers its ability to phosphorylate p100 (also known as NF-&kapp...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
Authors: Kasap B, Buruk CK, Kaklıkkaya N, Özkaya E, Aydın Kasap Z, Aydın F Abstract It has been estimated that currently 350-400 million people have been chronically infected with the hepatitis B virus (HBV) worldwide and approximately one million people die each year due to HBV related diseases. It has been suggested that the viral and host factors, especially the host immune system, may play a role in the chronicity of the HBV infection. Stimulator of interferon genes (STING) is one of the members of the pattern recognition receptor (PRR) that detects the presence of DNA in a human cell, activate synthesi...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Source: eMedicineHealth.com - Category: General Medicine Source Type: news
CONCLUSIONS: VVN has become the commonest cause of Hymenoptera anaphylaxis in our area. Most cases report no previous VVN stings. Their sensitization pattern is similar to that of patients with anaphylaxis to other Vespidae. Specific IgE to antigen-5 from VVN, Vespula spp., and Polistes dominula are strongly correlated in patients with VVN anaphylaxis. PMID: 32043465 [PubMed - as supplied by publisher]
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
Zhou et  al. generate an antibody that selectively inhibits efferocytosis by the phagocytic receptor MerTK and show that MerTK blockade increases tumor immunogenicity and potentiates anti-tumor immunity via the transfer of tumor-derived cGAMP into tumor-associated macrophages (TAMs) through the ATP-gated c hannel P2X7R and subsequent STING activation.
Source: Immunity - Category: Allergy & Immunology Authors: Tags: Article Source Type: research
When I was around 12 years old, I came upon a game being played by a group of boys from the neighborhood. They invited me to play with them, telling me that the game was called butts up. I didn’t know how to play, so they briefly explained the rules. It’s a fairly simple game played with a single ball (like a tennis ball or racketball) thrown against a wall. It didn’t sound too complicated, and I liked games, so I figured I’d give it a try. What they didn’t explain at the time was the penalty for making a mistake three times. Since I was new to the game, I didn’t have any issues with ...
Source: Steve Pavlina's Personal Development Blog - Category: Psychiatry & Psychology Authors: Tags: Emotions Values Source Type: blogs
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