Itraconazole, an Oral Antifungal Drug, Is Active in Chemotherapy Resistant B-Cell Non-Hodgkin Lymphoma and Enhances the Anti-Tumor Activity of Chemotherapy Agents

Itraconazole, an Oral Antifungal Drug, Is Active in Chemotherapy Resistant B-Cell Non-Hodgkin Lymphoma and Enhances the Anti-Tumor Activity of Chemotherapy AgentsConference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news

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Conclusions: Treatment outcome of PRCA depended upon the causes and the types of treatment, and the burden of RBC transfusion was very high in patients with ESA and thymoma-associated PRCA. PMID: 32257434 [PubMed]
Source: Anemia - Category: Hematology Tags: Anemia Source Type: research
This case involves a 51-year-old man with stage IA lymphocyte-predominant Hodgkin lymphoma (LP-HL) of the submental region status post excisional biopsy.1
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
For stage IA, nonbulky, nodular lymphocyte-predominant Hodgkin lymphoma involving a single submental lymph node, the current standard of care is involved-site radiation therapy alone to a dose of 30 Gy in conventional fractionation. Retrospective series have shown excellent long-term outcome with radiation therapy (RT) alone. A  study from the German Hodgkin Study Group on stage I patients reported an 8-year progression-free survival (PFS) rate of 91.9% after involved-field radiation therapy.1 With positron emission tomography staging, and modern RT techniques to more limited volumes, the PFS rates and toxic...
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Treatment approaches for nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) vary widely from observation to combined systemic therapy/radiation therapy (RT).1 Recommendations commonly depend on the disease burden at presentation. Prior studies including pediatric2 and adult3 patients have reported outcomes after observation of resected NLPHL and found 5-year event-free/progression-free survival rates of 77% and 59%, respectively, with no difference in overall survival for observed versus treated patients.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Gray Zone Source Type: research
Authors: Moellhoff N, Frank K, Wiggenhauser PS, Schenck TL, Mayr D, Giunta RE Abstract Elective surgeries, especially aesthetic operations in plastic surgery, require surgeons to provide a holistic and comprehensive explanation of possible procedural risks and long-term consequences. Recently, the use of breast implants for aesthetic breast augmentation or breast reconstruction after tumour resection has gained public attention as the numbers of patients with rare breast implant-associated diseases have been rising worldwide, while the aetiopathogenesis remains unclear. BIA-ALCL was classified as a lymphatic neopla...
Source: Handchirurgie Mikrochirurgie Plastische Chirurgie - Category: Cosmetic Surgery Tags: Handchir Mikrochir Plast Chir Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conclusion: This prospective multicenter study provides information on the current incidence and outcome of IFD in the real life setting. Practice variation between the centers may help to ultimately improve antifungal management in children at highest risk for IFDs. Introduction Available data on the incidence and outcome of invasive fungal diseases (IFD) in children treated for a hematological malignancy or undergoing allogeneic hematopoietic stem cell transplantation (HSCT) are mostly based on single site, retrospective studies or on studies performed prior to the availability of newer compounds such as broad-sp...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
Background: Monitoring of the Aspergillus galactomannan (GM) antigen is an useful tool for early diagnosis of aspergillosis, especially in patients with hematologic malignancies. However, one of the major limitations of this assay is false-positivity, which has been described in pediatric patients, patients with graft-versus-host disease, and those taking dietary GM or certain antibiotics. Only a few studies have shown high incidence of false-positive GM test results in patients with multiple myeloma (MM). Here we investigated the prevalence of false-positive GM test results in healthy subjects and in patients with hematol...
Source: Blood - Category: Hematology Authors: Tags: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster II Source Type: research
DISCUSSION: AIFRS should be considered in the differential diagnosis of immunocompromised patients with nonspecific sinonasal symptoms. Usually, AIFRS is diffuse with multiple sinus involvement; however, isolated sphenoid AIFRS can occur. This is one of the few cases of AIFRS demonstrating isolated sphenoid involvement and is thought to be the first case showing a synchronous noninvasive fungal ball of another sinus cavity. Prompt recognition and surgical treatment may be curative and lifesaving. PMID: 29236649 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
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