Long-term Antibiotics Ease Symptoms of Genetic Lung Disorder Long-term Antibiotics Ease Symptoms of Genetic Lung Disorder

Azithromycin improves symptoms for patients with primary ciliary dyskinesia, but researchers caution that vigilance must be maintained to prevent antibiotic resistance.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Pulmonary Medicine News Source Type: news

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DISCUSSION: Genetic testing, not related to her PKD diagnosis, revealed several mutations that could offer an explanation for the apparent efficacy of parenteral therapy in this patient. PMID: 31634116 [PubMed - in process]
Source: The Permanente journal - Category: General Medicine Tags: Perm J Source Type: research
Mutations in PURA (coding for purine-rich element binding protein A) have recently been shown to cause the neurodevelopmental disorder previously associated with 5q31.3 microdeletion syndrome1,2. To date, children with PURA syndrome have been described with neonatal hypotonia, hypersomnolence, hypothermia, respiratory compromise, and feeding difficulties. All reported patients have moderate-severe neurodevelopmental delays with some later developing epilepsy and nonepileptic hyperkinetic movements (dystonia, dyskinesia, eye movement abnormalities).
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Short Communication Source Type: research
Authors: Leta V, Jenner P, Chaudhuri KR, Antonini A Abstract Introduction: Dyskinesia is a motor complication of Parkinson's disease (PD) characterized by clinical heterogeneity and complex pathogenesis and associated with long-term levodopa therapy. Recent and controversial views on the management of PD patients have suggested that overall dyskinesia rates, and particularly troublesome dyskinesia, may be declining due to more conservative levodopa dosing regimens, widespread availability and early introduction of deep brain stimulation, and use of continuous drug delivery strategies. Nevertheless, anti-dyskinetic ...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Claassen DO, Philbin M, Carroll B Abstract Introduction: Huntington's disease (HD)-associated chorea and tardive dyskinesia (TD) are hyperkinetic movement disorders that can have deleterious effects on patients' quality of life (QoL). Deutetrabenazine, a vesicular monoamine transporter 2 (VMAT2) inhibitor, was approved by the US Food and Drug Administration (FDA) for the treatment of HD-associated chorea and TD. It is structurally similar to tetrabenazine, an FDA-approved compound for treatment of chorea that is widely used off-label for treatment of TD, but has deuterium modifications that improve its pha...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
Publication date: Available online 14 October 2019Source: MethodsXAuthor(s): Antti Huotarinen, Sakari Leino, Raimo K. Tuominen, Aki LaaksoAbstractIn experimental deep brain stimulation of the subthalamic nucleus (STN HFS), stimulation currents just below the appearance threshold of stimulation-induced dyskinesias has often been used. The behavioral effect of STN HFS can be measured by the reversal of forelimb use asymmetry produced by hemiparkinsonism can be measured with the cylinder test among other tests. We used 18 Wistar rats with 6-hydroxydopamine induced hemiparkinsonism to test a customized scale to rate the severi...
Source: MethodsX - Category: Science Source Type: research
Publication date: Available online 14 October 2019Source: The Lancet Respiratory MedicineAuthor(s): Jane S Lucas, Stephanie D Davis, Heymut Omran, Amelia ShoemarkSummaryPrimary ciliary dyskinesia is a genetically and clinically heterogeneous syndrome. Impaired function of motile cilia causes failure of mucociliary clearance. Patients typically present with neonatal respiratory distress of unknown cause and then continue to have a daily wet cough, recurrent chest infections, perennial rhinosinusitis, otitis media with effusion, and bronchiectasis. Approximately 50% of patients have situs inversus, and infertility is common....
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Parkinson's disease is the second-most common neurodegenerative disorder worldwide. Besides deciphering the mechanisms that underlie the etiology of the disease, it is important to elucidate the factors that influence the efficacy of the treatment therapeutics. Levodopa, which remains the golden treatment of the disease, is absorbed in the proximal small intestine. A reduction in levodopa absorption, leads to reduction in striatal dopamine levels and, in turn, an “off”-episode. In fact, motor fluctuations represent a major problem during the progression of the disease and alteration between “on” (mo...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsPKD can be a manifestation of PFBC, and brain calcification may be a cause of secondary PKD. So thoroughly evaluation including head CT or genetic screening for paroxysmal dyskinesia and PFBC should be applied before the diagnosis of PKD or PFBC. Moreover, negative brain calcification may not exclude the possibility of PFBC. The possible pathogenesis of primary calcification lie in the dysfunction of the protein or defective signal transduction caused by the mutations.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 147Author(s): Xiaojiao Xu, Zhenfa Fu, Weidong LeAbstractParkinson's disease (PD) is one of the most common neurodegenerative diseases in the world. Unfortunately, most of the currently used clinical therapies against PD are symptomatic and there is still no remedy can stop disease progression. Collective evidence shows that various kinds of exercise may reduce the risk of PD and do have positive impacts on both motor and nonmotor symptoms of PD. Additionally, exercise can also ameliorate the side effects such as wearing-off and dyskinesia induced by...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
This article systematically reviews the history, the pros and cons, and the controversies surrounding rodent models of dyskinesia as well as their behavioral assessment protocols. A summary of factors that influence the behavioral assessment in the rodent dyskinesia models is also presented, including the degree of dopamine denervation, stereotaxic lesion sites, drug regimen, monitoring styles, priming effect, and individual and strain differences. Besides, recent breakthroughs like the genetic mouse models and the bilateral intoxication models for dyskinesia are also discussed.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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