Experimental anti-viral drug 'cures' three hand, foot and mouth disease sufferers in just three days

Doctors from Florida State University College of Medicine treated two brothers, aged two and four, and their mother, 37, with the drug acyclovir after they all developed the disease's tell-tale rash.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusions: These data reveal the variety of agents in the cases clinically diagnosed as HFMD.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
Enterovirus A71 (EV-A71) is one of the common causative pathogens for hand foot and mouth disease (HFMD) affecting young children. HFMD outbreak can result in a substantial pediatric hospitalization and burden...
Source: Journal of Biomedical Science - Category: Biomedical Science Authors: Tags: Review Source Type: research
Dear Editor,
Source: Journal of Infection - Category: Infectious Diseases Authors: Tags: Letter to the Editor Source Type: research
In this study, we achieved a murine mAb, named 5A3, specifically toward EVA71 2Apro by using the traditional hybridoma technique. The mAb 5A3 recognizes 2Apro of both EVs A and B species, which was demonstrated by indirect fluorescent assay and Western blotting. Furthermore, a conserved N-terminal epitope on 2Apro recognized by mAb 5A3 was defined by using an overlapping peptide-based enzyme-linked immunosorbent assay (ELISA). Therefore, the unique mAb targeting conserved EVs 2Apro can be used as an important tool during both identifying the causative agent of HFMD and elucidating the pathological mechanism of HFMD. PM...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Source: Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Hand, foot and mouth disease (HFMD) is a rising public health problem and has attracted considerable attention worldwide. The purpose of this study was to develop an optimal model with meteorological factors t...
Source: BMC Infectious Diseases - Category: Infectious Diseases Authors: Tags: Research article Source Type: research
In this study, we aim to identify biomarker which are associated with for severity of EV71 infection cases using high-throughput RNA sequencing approach. RNA sequencing of samples from severe HFMD (S) patients group (nā€Š=ā€Š10) and control HFMD (C) patients group (nā€Š=ā€Š10) were performed and the results were verified by qPCR. mRNA with the highest expression level was selected to be validated in an independent cohort comprising of 45 severe EV71 infected patients and 45 control by qPCR assay. Seventeen significant differentially expressed genes were identified. Scavenger receptor class A, member 3 (SCARA3) was one of...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
ConclusionsFor the subset of mccRCC pts with disease progression during or following ICI therapy, LEN + PEMBRO demonstrated promising antitumor activity. No new safety signals were detected. The study will continue to full cohort expansion. Table:1187PD Summary of patient characteristics and efficacy outcomesPatient Characteristics, n (%)LEN + PEMBRO (n  = 33)ECOG performance status018 (54.5)115 (45.5)Prior anticancer regimens1 prior regimen14 (42%)>1 prior regimen19 (58%)Prior VEGF-targeted therapy26 (78.8%)Prior ICI therapy33 (100%)PD-1/PD-L1 monotherapy14 (42.4%)with VEGF agents9 (27.7%)nivolumab + ipil...
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research
Abstract Hand-foot-and-mouth disease is caused by human enteroviruses and coxsackieviruses. Outbreaks can occur in the spring to fall and are common in North America, and most cases occur in patients younger than 10 years. Hand-foot-and-mouth disease is transmitted by fecal-oral, oral-oral, and respiratory droplet contact. Patients present with a low-grade fever, a maculopapular or papulovesicular rash on the hands and soles of the feet, and painful oral ulcerations. Lesions usually resolve in seven to 10 days; however, in rare cases, patients may have neurologic or cardiopulmonary complications. The differential ...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
In this study we found that CV-A6 shows the greatest transmission ability among these three pathogens while EV-A71 exhibits the weakest ability of transmission, and moreover, the estimated values of basic reproduction number in northwest China are lower than those in Singapore, Hongkong and Guangdong, which may be due to different climatic circumstances.
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
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