Transplant recipient and donor family who are fans of opposing teams throw out first pitch together
Tom Schroeder, 62, of Cedarburg, Wisconsin, met the family of his heart donor Josh Holland, 32, of Streator, Illinois, at a Milwaukee Brewers-Chicago Cubs game in September.
Condition: Transplant; Decision-making Interventions: Other: Total Survival; Other: Stratified Transplant Survival Sponsor: Carnegie Mellon University Not yet recruiting
Pseudomonas aeruginosa (P. aeruginosa) is a common pathogen in the setting of lung transplantation.1 Most recipients become chronically colonized with P. aeruginosa. Previously we have demonstrated in a subgroup of patients with non-cystic fibrosis (CF) bronchiectasis who are chronically colonized with P. aeruginosa, the presence of high titres of IgG2 antibodies specific for the O-antigen of lipopolysaccharide (LPS) which impair serum-mediated killing of the cognate strain.2 In contrast to the serum bactericidal effect normally associated with antibody, this ‘inhibitory antibody’ prevented immune killing of the infecting strain.
Cardiac valve operations in patients who had undergone solid organ (kidney, liver, pancreas, heart and lung) transplantation pose unique challenges, due to the patient comorbidities and to the need for immunosuppressive therapy. Aim of this retrospective study was to present our experience with solid-organ transplanted patients who had undergone cardiac valve operation at the time or after transplantation.
Publication date: Available online 19 October 2019Source: The Annals of Thoracic SurgeryAuthor(s): Leona T. Yarboro
ConclusionsRisk stratification for cardiac amyloidosis with the newly developed “HeiRisk” score may be superior to other staging systems for patients with advanced heart failure due to amyloid cardiomyopathy.
CONCLUSIONS: Risk stratification for cardiac amyloidosis with the newly developed "HeiRisk" score may be superior to other staging systems for patients with advanced heart failure due to amyloid cardiomyopathy. PMID: 31630214 [PubMed - as supplied by publisher]
Publication date: October 2019Source: Clinical Lymphoma Myeloma and Leukemia, Volume 19, Issue 10, SupplementAuthor(s): Inhwan Hwang, Dok Hyun Yoon, Cheolwon Suh, Jea-Joong kim, Chan-Jeoung Park, Jae Won Lee, Tae-Jin Yun, Sung Ho Jung, Min-Seok Kim, Heejung Chae
Publication date: Available online 16 October 2019Source: Pharmacological ResearchAuthor(s): Sivakkanan Loganathan, Yuxing Guo, Weipeng Jiang, Tamás Radovits, Mihály Ruppert, Alex Ali Sayour, Maik Brune, Paige Brlecic, Phillipp Gude, Adrian-Iustin Georgevici, Benito Yard, Matthias Karck, Sevil Korkmaz-Icöz, Gábor SzabóAbstractThe major source of heart transplantation comes from brain-dead (BD) donors. However, brain death and myocardial ischemia/reperfusion injury during transplantation may lead to cardiac dysfunction and hemodynamic instability. A previous work demonstrated that pre-treatm...
Conclusions: Interval exercise was well tolerated and preferred by participants with advanced ILD. PMID: 31625781 [PubMed - as supplied by publisher]
Abstract Dilated cardiomyopathy (DCM) is the most common cause of heart failure (HF) in children, resulting in high mortality and need for heart transplantation. The pathophysiology underlying pediatric DCM is largely unclear, however there is emerging evidence that molecular adaptations and response to conventional HF medications differ between children and adults. In order to gain insight into alterations leading to systolic dysfunction in pediatric DCM, we measured cardiomyocyte contractile properties and sarcomeric protein phosphorylation in explanted pediatric DCM myocardium (N=8) compared to non-failing (NF)...