Guideline Inclusion Could Open More Doors for WATS3D

CDx Diagnostics has some extra firepower behind the WATS3D diagnostic platform. The Suffern, NY-based company said the diagnostic has been included in the American Society for Gastrointestinal Endoscopy’s Standards of Practice Committee’s guideline for the screening and surveillance of Barrett’s esophagus. Since esophageal dysplasia is both highly focal and typically invisible, the effectiveness of upper endoscopy is widely recognized to be limited by the high rate of false-negative sampling error associated with standard 4-quadrant random biopsy. WATS3D, or Wide Area Transepithelial Sampling with 3D Tissue Analysis, addresses this limitation by using an abrasive sampling brush to create a wide area tissue sample that unlike standard cytology instruments also captures the full thickness of the epithelium, penetrating the submucosa. This comprehensive tissue sample had not been attempted before since it is up to 50 times thicker than the depth of field of a standard laboratory microscope. Bill Huffnagle, who took over the role of CEO in May, said the new guidelines could help with adoption and give company personnel validation for the work they have done on WATS3D. “We’re extremely proud of the guidelines now including WATS3D as an adjunct to forceps biopsy for the screening and surveillance as known and suspected variance and dysplasia,” Huffnagle told MD+DI. â...
Source: MDDI - Category: Medical Devices Authors: Tags: Imaging Source Type: news

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Esophagogastroduodenoscopy (EGD) has been used for secondary prevention of upper gastrointestinal neoplasia (UGIN), especially gastric cancer (GC) in Asian countries. In contrast to screening colonoscopy, there are few established quality indicators for EGD. Endoscopist biopsy rate (EBR) was recently reported to be promising candidate of quality indicator of EGD because of its possible association with disease detection rate. The aim of this study was to validate the association between EBR and UGIN (GC, esophageal cancer (EC), gastric adenoma (GA), duodenal adenoma (DA)) detection rate in Asian population where GC is prevalent.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Poster abstracts Source Type: research
Conclusions Scopolamine use did not appear to effectively facilitate detection of gastric or esophageal cancer, gastric or duodenal adenoma, and UGIN during screening EGD. Scopolamine should be avoided until its efficacy is confirmed by a randomized controlled trial. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionThe majority of patients with EE demonstrated healing at follow-up endoscopy regardless of continued PPI use. A small proportion developed Barrett ’s esophagus, including those with LA grade A and B esophagitis, highlighting a potential role for repeat endoscopy in all grades of EE. A more conservative long-term PPI strategy may be reasonable in patients with LA grade A or B esophagitis in the absence of hiatal hernia.
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
There have been numerous technologic advances in upper endoscopy in recent years, with an emphasis on early diagnostics. Still, the incidence of esophageal cancer has continued to rise over the past several decades, and through 2018 it remained the sixth leading cause of all cancer deaths, with more than 500,000 deaths worldwide.1 The 5-year survival rate remains low, at approximately 15% to 20%.1
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
AbstractPurpose of reviewWith a globally aging population, dysphagia is a growing health concern among elderly. Increasing reflux disease has contributed to an increased prevalence of dysphagia from peptic strictures and esophageal cancer. Dysphagia can lead to malnutrition and aspiration pneumonia, causing considerable morbidity and mortality. This review article focuses on recent advances in the approach and management of esophageal dysphagia.Recent findingsEndoscopic functional luminal imaging probe is a novel test that complements upper endoscopy, esophagram, and esophageal manometry for evaluation of esophageal dyspha...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionsA simple combination of the variables age, sex and maximum BE length showed fairly good accuracy for predicting tumor progression in BE. This clinical risk prediction model may help to tailor future surveillance programs.
Source: Surgical Endoscopy - Category: Surgery Source Type: research
CONCLUSION: Chromoendoscopy with toluidine blue combined with Lugol ’ s solution is a useful tool in the screening of esophageal premalignant lesions and superficial neoplasms.RESUMO CONTEXTO: O c âncer de esôfago é o oitavo câncer mais comum. O prognóstico é sombrio em pacientes com estágios avançados. Pacientes com doença precoce têm um melhor prognóstico do que aqueles com estágio avançado. Existem várias técnicas para a triagem de lesões pré-malignas e superficiais, inclu indo cromoendoscopia. OBJETI...
Source: Arquivos de Gastroenterologia - Category: Gastroenterology Source Type: research
ConclusionsUndiagnosed renal cell cancer metastasis presenting as dysphagia is very rare. Careful upper endoscopy examination contributed to the diagnosis of this rare entity. A multidisciplinary team approach is key for management of these clinical dilemmas.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Cancer of the esophagus is often related to chronic heartburn, something patients too often end up ignoring. The onset of the potentially deadly disease can be detected, though, given good enough imaging and regular screenings. The imaging component,...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive GI Pathology Surgery Source Type: blogs
Abstract Esophageal carcinoma is a highly lethal cancer associated with high morbidity and mortality. Esophageal squamous cell carcinoma and esophageal adenocarcinoma are the two distinct histological types. There has been significant progress in endoscopic diagnosis and treatment of early stages of cancer using resection and ablation techniques, as shown in several trials in the recent past. Earlier detection of esophageal cancer and advances in treatment modalities have lead to improvement in the 5-year survival from 5% to about 20% in the past decade. Endoscopic eradication therapy is the preferred modality of ...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
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