Sternal Reconstruction with Non-Rigid Biologic Mesh Overlay.
We present the case of a large sternal defect after chondrosarcoma resection reconstructed with porcine acellular dermal matrix and soft tissue flaps, without rigid component, with excellent patient outcome through 2 years of follow-up. PMID: 31580854 [PubMed - as supplied by publisher]
Conditions: Chondrosarcoma; Chondrosarcoma, Grade 2; Chondrosarcoma, Grade 3; IDH1 Gene Mutation Intervention: Drug: AG-120 Sponsors: Memorial Sloan Kettering Cancer Center; Agios Pharmaceuticals, Inc. Not yet recruiting
Publication date: February 2020Source: Journal of Bone Oncology, Volume 20Author(s): Iseulys Richert, Anne Gomez-Brouchet, Corinne Bouvier, Gonzague Du Bouexic De Pinieux, Marie Karanian, Jean-Yves Blay, Aurélie DutourAbstractSurvival rate for Chondrosarcoma (CHS) is at a standstill, more effective treatments are urgently needed. Consequently, a better understanding of CHS biology and its immune environment is crucial to identify new prognostic factors and therapeutic targets.Here, we exhaustively describe the immune landscape of conventional and dedifferentiated CHS. Using IHC and molecular analyses (RT-qPCR), we m...
CONCLUSION: Therefore, apart from probable anti-cancerous effect of rTC-1 on C26-A and SW1353 cell lines, this peptide may be able to mimic the anti-cancerous pathway of IL-8. PMID: 32072885 [PubMed - as supplied by publisher]
Authors: Collaud S, Stork T, Valdivia D, Tokuishi K, Aigner C PMID: 32055421 [PubMed]
Authors: Sandri A, Donati G, Blanc CD, Nigra VA, Gagliasso M, Barmasse R Abstract Chest wall tumours are heterogeneous neoplasms, either primary or metastatic, with a malignancy rate of 50%. Surgical resection is one of the mainstays of the treatment, however, chest wall resections can be particularly challenging depending onto the resection size, site and patient habitus. The surgical strategy should be carefully analysed preoperatively, keeping in mind the need of an oncological radical resection (R0) in accordance to the reconstruction principles elicited by le Roux and Sherma since 1983, which include restoring...
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Conditions: Efficacy; Toxicity, Drug Intervention: Drug: Apatinib Mesylate Sponsor: Peking University People's Hospital Active, not recruiting