Potential role of IL-37 signaling pathway in feedback regulation of autoimmune Hashimoto thyroiditis

AbstractIL-37, the anti-inflammatory cytokine of the IL-1 family, plays several key roles in the regulation of autoimmune diseases. Yet, its role in Hashimoto ’s thyroiditis (HT) is not clear. In the present study, we found that, in tissues from HT patients, most of the follicular epithelial cells were positive for both IL-37 and single Ig IL-1-related receptor (SIGIRR) by immunohistochemical staining, while the infiltrating lymphocytes and other inflam matory cells hardly expressed any. Meanwhile, mRNA expression levels of IL-37 in peripheral blood mononuclear cells (PBMC) of HT patients were significantly higher than those in normal controls measured by quantitative real-time PCR. Finally, we studied the possible role of IL-37 in IFN-γ-stimulate d rat FRTL-5 cells. The results showed that IL-1β, TNF-α, and MCP-1 mRNA levels were significantly decreased, while the expression of IL-4 mRNA was dramatically up-regulated in IFN-γ-stimulated rat thyroid cell line FRTL-5 pre-treated with IL-37. The current study, for the first time, demonstrate d that the IL-37 network is involved in Hashimoto’s thyroiditis, and IL-37 signaling pathway may ameliorate the excessive autoimmune responses in this chronic lymphocytic thyroiditis.
Source: Histochemistry and Cell Biology - Category: Biomedical Science Source Type: research

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Conclusions: One or more types of ADs developed in AE patients, and patients with anti-LGI1 encephalitis had a higher frequency of autoimmune comorbidities than those with anti-NMDAR encephalitis. And we found that autoimmune comorbidities did not affect the clinical course of AE.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsThe detected alterations of serum protein sialylation might be caused by chronic inflammation in HT. The obtained results completed our previous IgG N-glycosylation analysis in autoimmune thyroid patients and showed that the altered N-glycosylation of serum proteins is characteristic for autoimmunity process in HT.General Significance:Thyroid autoimmunity is accompanied by changes of serum protein sialylation.Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Abstract In Western countries, about 5% of the population is affected by an autoimmune disease; in the United States, up to 23.5 million Americans suffer from autoimmune disorders [1]. Women comprise over 80% of the affected individuals for many autoimmune conditions, including Sjögren's syndrome, systemic sclerosis, Addison's disease, primary biliary cirrhosis, systemic lupus erythematosus (SLE), and autoimmune thyroid diseases like Grave's disease and Hashimoto's thyroiditis [2]. Additionally, the prevalence of rheumatoid arthritis, multiple sclerosis, and Sjögren's syndrome is also skewed towards wome...
Source: Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Clin Immunol Source Type: research
Authors: Inaba H, Ariyasu H, Takeshima K, Iwakura H, Akamizu T Abstract Various thyroid diseases are associated with autoimmunity. Major autoimmune thyroid diseases are Graves' disease (GD) and Hashimoto's thyroiditis (HT). Thyrotropin receptor is an autoantigen in GD, and its immunogenicity has been examined. Immune-checkpoint inhibitor (ICI) is recently widely used for treatment of malignant tumors, but cases of thyroid diseases during ICI treatment have been increasing. Thyroid diseases during ICI therapy have been investigated in immunological and clinical aspects, and their Japanese official diagnostic guideli...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
This study raises the possibility of a role for surgery for patients with Hashimoto’s thyroiditis who continue to feel poorly despite optimal treatment with thyroid hormone. However, the study, while well done, is a relatively small one. We need longer-term follow up and confirmation with additional studies done on diverse populations. It’s also important to consider that thyroid surgery in patients with advanced Hashimoto’s thyroiditis is difficult. Rates of complications, including injury to the laryngeal nerve (which controls voice) and the parathyroid glands (which maintain normal blood calcium levels...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Thyroid Disorders Source Type: blogs
ConclusionsRFA was effective in patients with PTMC+CLT, and its therapeutic efficacy and safety were similar to those in patients with PTMC without CLT.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Authors: Kumar SSS, Palaniandavan S, Bhargavi MV, Gambeer AS, Nithyalakshmi G Abstract Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and it often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. A 30-year-old woman presented with complaints of headache for 1 year on and off. Physical examination revealed nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultraso...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
In conclusion, this study provides the first evidence for a genetic association between GD and the PER3 gene, highlighting the possible relevance of polymorphisms in clock genes in the etiopathogenesis of AITD. However, functional studies to identify the underlying molecular mechanisms of this association are needed to translate these findings to clinical applications. PMID: 31328557 [PubMed - as supplied by publisher]
Source: Chronobiology International - Category: Biology Authors: Tags: Chronobiol Int Source Type: research
The objective of our study is to investigate how often ABO and Rh blood groups are seen in benign thyroid diseases, especially in autoimmune-mediated thyroid diseases, and hence whether there is an association between blood groups and thyroid diseases. A total of 958 patients who were followed due to any benign thyroid disease were included in the study. The study population comprised 958 patients, 550 with Hashimoto's hypothyroidism, 160 with non-Hashimoto's hypothyroidism, 103 with iatrogenic hypothyroidism, 93 with central hypothyroidism, and 28 with Graves' and 24 with non-Graves' hyperthyroidism. Of the patients, 47.1...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Abstract The two most common autoimmune conditions of the thyroid include chronic lymphocytic (Hashimoto's) thyroiditis and Graves' disease. Both conditions can be treated medically, but surgery plays an important role. Hashimoto's thyroiditis and Graves' disease are mediated by autoantibodies that interact directly with the thyroid, creating inflammation and impacting thyroid function. Patients may develop large goiters with compressive symptoms or malignancy requiring surgical intervention. In addition, there are several surgical indications specific to Hashimoto's and Graves' Disease. PMID: 31255196 [PubMed - in process]
Source: The Surgical Clinics of North America - Category: Surgery Authors: Tags: Surg Clin North Am Source Type: research
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