Effects of curcumin on mitochondria in neurodegenerative diseases

AbstractNeurodegenerative diseases (NDs) result from progressive deterioration of selectively susceptible neuron populations in different central nervous system (CNS) regions. NDs are classified in accordance with the primary clinical manifestations (e.g., parkinsonism, dementia, or motor neuron disease), the anatomic basis of neurodegeneration (e.g., frontotemporal degenerations, extrapyramidal disorders, or spinocerebellar degenerations), and fundamental molecular abnormalities (e.g., mutations, mitochondrial dysfunction, and its related molecular alterations). NDs include the Alzheimer disease and Parkinson disease, among others. There is a growing evidence that mitochondrial dysfunction and its related mutations in the form of oxidative/nitrosative stress and neurotoxic compounds play major roles in the pathogenesis of various NDs. Curcumin, a polyphenol and nontoxic compound, obtained from turmeric, has been shown to have a therapeutic beneficial effect in various disorders especially on the CNS cells. It has been shown that curcumin has considerable neuro ‐ and mitochondria‐protective properties against broad‐spectrum neurotoxic compounds and diseases/injury‐associating NDs. In this article, we have reviewed the various effects of curcumin on mitochondrial dysfunction in NDs.
Source: BioFactors - Category: Biochemistry Authors: Tags: REVIEW ARTICLE Source Type: research

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CONCLUSIONS: In this review, biological and chemical knowledge of melatonin, its experimental effects, and the clinical impact on patients with neurological disorders were described. According to all of the beneficial results obtained from experimental and clinical trials, melatonin may have a prophylactic and therapeutic effect on neurological diseases. Strong collaboration between neurologists and health service policy makers is needed to encourage use of melatonin in the patients suffering from neurological diseases. Melatonin may be the solution we have been looking for. PMID: 31718830 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Publication date: Available online 13 November 2019Source: Stem Cell ResearchAuthor(s): Muwan Chen, Muyesier Maimaitili, Susanne Hvolbøl Buchholdt, Uffe Birk Jensen, Fabia Febbraro, Mark DenhamAbstractWe generated eight induced pluripotent stem cell (iPSC) lines from Parkinson's disease (PD) patients with different familial mutations using non-integrating episomal plasmids. All iPSC lines have a normal karyotype, express pluripotent genes including POU5F1, NANOG, and show alkaline phosphatase activity, as well as the ability to differentiate into all three germ layers. These PD iPSC lines can be used for disease mod...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
DISCUSSION: CMDs, especially when comorbid, are associated with increased dementia risk; however, leisure activities and social integration mitigate this risk. PMID: 31718906 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Liu Q, Yuan JW, Zhang F, Qiao F, Sui XF, Liu CH PMID: 31713403 [PubMed - as supplied by publisher]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Innovation may help guide treatment of Alzheimer's, Parkinson's diseases More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=299569&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
Dear Candid Caregiver: I’m a divorced, middle-aged woman who’d very much enjoy a relationship but I can’t even date because my mother gets mad when I do. I thought that I’d left this behind after high school but I’m obviously wrong. Mom had a stroke two years ago and recovered as well as can be expected. Other than having a slight limp, there’s little physical sign of what she went through. The problem is that six months after her stroke, she was diagnosed with a combination of vascular dementia and Alzheimer’s dementia. I moved her in with me so that I could provide care when...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
ConclusionsCoupling various oscillations could provide potentially useful information for large-scale network and progressive oscillation-specific nodal alterations were observed in PD patients across early to middle stages.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
ConclusionsQRS morphology of syn-V4R lead may be useful for predicting accessory pathway location of manifest WPW syndrome.
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
Traumatic brain injury (TBI) and Alzheimer's disease (AD) bear a complex relationship, potentially increasing risk of one another reciprocally. However, recent evidence suggests post-TBI dementia exists as a distinct neurodegenerative syndrome, confounding...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Conclusion The key problem with the ND field is the lack of understanding in the events preceding the development of protein-based markers – such as Tau – currently used to diagnose NDs. By this stage, the diseases become more difficult to treat. SncRNAs play an important regulatory role in the maintenance of the homeostatic brain. Therefore, changes in their concentration levels can be indicative of mechanistic changes that could precede protein-based markers. One single sncRNA biomarker is unlikely to differentiate between diseases. However, a combination of sncRNA biomarkers could be illustrative of the me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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