IJERPH, Vol. 16, Pages 3751: The Gut-Microbiome in Gulf War Veterans: A Preliminary Report
IJERPH, Vol. 16, Pages 3751: The Gut-Microbiome in Gulf War Veterans: A Preliminary Report
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16193751
Authors:
Janulewicz
Seth
Carlson
Ajama
Quinn
Heeren
Klimas
Lasley
Horner
Sullivan
Chatterjee
Gulf War Illness (GWI) is a chronic multi-symptom disorder affecting the central nervous system (CNS), immune and gastrointestinal (GI) systems of Gulf War veterans (GWV). We assessed the relationships between GWI, GI symptoms, gut microbiome and inflammatory markers in GWV from the Boston Gulf War Illness Consortium (GWIC). Three groups of GWIC veterans were recruited in this pilot study; GWV without GWI and no gastrointestinal symptoms (controls), GWV with GWI and no gastrointestinal symptoms (GWI-GI), GWV with GWI who reported gastrointestinal symptoms (GW+GI). Here we report on a subset of the first thirteen stool samples analyzed. Results showed significantly different gut microbiome patterns among the three groups and within the GWI +/−GI groups. Specifically, GW controls had a greater abundance of firmicutes and the GWI+GI group had a greater abundance of the phyla bacteroidetes, actinobacteria, euryarchaeota, and proteobacteria as well as higher abundances of the families Bacteroidaceae, Erysipelotrichaceae, and Bifidobacteriaceae. The GWI+GI group also showed greater plasma levels of the inflammatory cytokine TNF-RI and they endorsed signific...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Janulewicz Seth Carlson Ajama Quinn Heeren Klimas Lasley Horner Sullivan Chatterjee Tags: Article Source Type: research
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