<Editors' Choice> Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer.

<Editors' Choice> Renewed Japanese spirometric reference variables and risk stratification for postoperative outcomes in COPD patients with resected lung cancer. Nagoya J Med Sci. 2019 Aug;81(3):427-438 Authors: Okada Y, Hashimoto N, Iwano S, Kawaguchi K, Fukui T, Sakamoto K, Wakai K, Yokoi K, Hasegawa Y Abstract Although the lower limit of normal (LLN) of FEV1/FVC detects at-risk patients for postoperative outcomes among Japanese chronic obstructive pulmonary disease (COPD) patients with resected lung cancer, there was a lack of a Japanese reference equation to calculate the LLN of FEV1/FVC. Renewed Japanese spirometric reference variables might enable us to verify clinical impact of the LLN of FEV1/FVC among the Japanese population. To evaluate the clinical impact of the LLN of FEV1/FVC by using this renewed reference, data were retrospectively analyzed from 609 newly diagnosed lung cancer patients who had undergone thoracic surgery between 2006 and 2011. The combined assessment of the 0.70 fixed ratio and the LLN of the FEV1/FVC ratio classified the 609 subjects into the COPD (214 subjects), non-COPD (337 subjects), and in-between (58 subjects) groups, respectively. All of the relative odds ratios (ORs) of postoperative outcomes for the comparison between the in-between and non-COPD groups did not show significant confidence intervals (CIs). On the other hand, the adjusted ORs of postoperative outcomes for the COPD group versus the non-COPD group w...
Source: Nagoya Journal of Medical Science - Category: International Medicine & Public Health Tags: Nagoya J Med Sci Source Type: research

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ABSTRACT Objective: Preoperative functional evaluation is central to optimizing the identification of patients with non-small cell lung cancer (NSCLC) who are candidates for surgery. The minute ventilation/carbon dioxide output (VE/VCO2) slope has proven to be a predictor of surgical complications and mortality. Pulmonary rehabilitation programs (PRPs) could influence short-term outcomes in patients with COPD undergoing lung resection. Our objective was to evaluate the effects of a PRP on the VE/VCO2 slope in a cohort of patients with COPD undergoing lung resection for NSCLC. Methods: We retrospectively evaluated 25 consec...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
A major U.S. tobacco company on Saturday issued a press release boasting that smoking its cigarettes is no more harmful than vaping an e-cigarette that contains no tobacco and involves no combustion, at least in terms of lung disease. A spokesperson for the company was kind enough to allowThe Rest of the Story to interview him. The transcript appears below, with only slight editing for purposes of clarity. I was given permission to publish the interview, but under the condition that I not name the spokesperson.The Rest of the Story: Let me first make sure I have this correctly. You are saying that in terms of lung disease,...
Source: The Rest of the Story: Tobacco News Analysis and Commentary - Category: Addiction Source Type: blogs
Yafei Tan1,2, Omer Van den Bergh2, Jiang Qiu1* and Andreas von Leupoldt2* 1Faculty of Psychology, Southwest University, Chongqing, China 2Health Psychology, KU Leuven, Leuven, Belgium Dyspnea is a prevalent interoceptive sensation and the aversive cardinal symptom in many cardiorespiratory diseases as well as in mental disorders. Especially the unpredictability of the occurrence of dyspnea episodes has been suggested to be highly anxiety provoking for affected patients. Moreover, previous studies demonstrated that unpredictable exteroceptive stimuli increased self-reports and electrophysiological responses of an...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The increasingly female face of chronic obstructive pulmonary disease (COPD) prevalence among women has equalled that of men since 2008, due in part to increased tobacco use among women worldwide and exposure to biomass fuels. This finding is supported by a number of characteristics. There is evidence of susceptibility to smoking and other airborne contaminants, along with epidemiological and phenotypic manifestations. COPD has thus become the leading cause of death in women in the USA. The clinical presentation is characterised by increasingly pronounced dyspnoea with a marked tendency towards anxiety and depression, unde...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: COPD and smoking Review Source Type: research
Abstract BACKGROUND: COPD is a leading cause of morbidity and mortality worldwide. Spirometry is the most common lung function test for diagnosing COPD with a post-bronchodilator FEV1/FVC
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Care Source Type: research
Rationale: Lung resection is the best treatment for patients with early stage non-small cell lung cancer (NSCLC) and Cardiopulmonary Exercise Test (CPET) has been shown to be a reliable method for stratification of surgical risk. VO2max is the most used variable for this purpose, however gas exchange markers of ventilatory inefficiency might also have a role in predicting outcomes.Objective: To evaluate risk factors for postoperative complications in lung resection for non-small cell lung cancer.Methods: Fifty-five patients (63 ± 11 yrs, 60% male) were prospectively evaluated from 2014 to 2017 for lung resection. Th...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
Background: Alterations in antitumor immunity might play an important role in the pathogenesis of lung cancer (LC) in COPD. PD1 is an inhibitory co-stimulatory molecule whose expression is increased on the surface of T cells after sustained inflammatory stimulation. As a consequence, the immune response can be inhibited and promote carcinogenesis.Hypothesis: The PD1 molecule is overexpressed in the T lymphocytes of patients with COPD and could enable the LC/COPD association.Objectives: To compare the expression of PD1 in T cells in blood of patients with COPD (with/without LC) and in non-COPD patients (with/without LC). We...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Conclusion: Pneumonitis after SBRT occur later than after CRT. Although a high percentage of the patients receiving curatively intended radiotherapy developed radiation pneumonitis, this was not reflected in the health related quality of life as measured by CCQ.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
We report the case of a tracheal chondrosarcoma with malignant infiltration of the thyroid gland, initially misdiagnosed as COPD.A 67-year-old female was referred with recent haemoptysis on a background of a several month history of increasing dyspnoea and wheeze. She remained otherwise well and denied any associated symptoms. Her past medical history included atrial fibrillation and she was an ex-smoker of less than 2-pack years having stopped over 50 years ago. In view of her symptoms, she was diagnosed with COPD in primary care and only referred in the wake of new haemoptysis. Clinical examination revealed a marked uppe...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung Cancer Source Type: research
Background: Undiagnosed obstructive lung disease (OLD) is common (around 70%) among American adults. Lung Cancer Screening Programs provide a unique opportunity to diagnose OLD in a high risk population.Objective: To determine the proportion of undiagnosed and miss-diagnosed OLD.Methods: We explored the NLST-ACRIN database that included 13831 smokers, age 55-74 yrs with at least 30 pack-years history that underwent a spirometry. OLD was defined per GOLD criteria with a FEV1/FVC ratio
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
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