Anti-hyperglycemic and anti-hyperlipidemic effects of a special fraction of Luohanguo extract on obese T2DM rats

ConclusionL-SGgly, fractions separated from LHG extract, were verified to have obvious anti-hyperglycemic and anti-hyperlipidemic effects on T2DM rats. Furthermore, L-SGgly regulated insulin secretion in T2DM rats by increasing GLP-1 levels. These findings provide an explanation for the antidiabetic role of LHG.Graphical abstractL-SGgly can play a role in anti-hyperglycemia and anti-hyperlipidemia by increasing the levels of GLP-1. L-SGgly were the active antidiabetic components of LHG.
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research