p16 promoter methylation, expression, and its association with estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 subtype of breast carcinoma

Conclusion: High p16 protein expression was associated with ER-positive, PR-negative, and HER2-negative tumors which is associated with poor prognosis. p16 protein expression may be used as a prognostic indicator to predict treatment response to hormonal therapy.

Source: Journal of Cancer Research and Therapeutics - October 3, 2019 Category: Cancer & Oncology Authors: Aditi Goyal Ram Krishna Sahu Mohit Kumar Sonal Sharma Shariq Qayyum Navneet Kaur Usha Rani Singh Ravi Mehrotra Suresh Hedau Source Type: research