Propagation of tau pathology: integrating insights from post mortem and in vivo studies
Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer ’s disease (AD), progressive supranuclear palsy (PSP), and chronic traumatic encephalopathy (CTE). A growing body of literature suggests that conformational characteristics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct histopathological morphologies , biochemical composition and affected cell types seen across these disorders.
Source: Biological Psychiatry - Category: Psychiatry Authors: Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Sch öll Tags: Review Source Type: research