Propagation of tau pathology: integrating insights from post mortem and in vivo studies

Cellular accumulation of aggregated forms of the protein tau is a defining feature of so-called tauopathies such as Alzheimer ’s disease (AD), progressive supranuclear palsy (PSP), and chronic traumatic encephalopathy (CTE). A growing body of literature suggests that conformational characteristics of tau filaments, along with regional vulnerability to tau pathology, account for the distinct histopathological morphologies , biochemical composition and affected cell types seen across these disorders.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research