Treading lightly as we step into a new era: Use of hepatitis C virus-infected organs for transplantation

An unprecedented number of heart transplants were performed in the United States during 2016,1 yet 15% of patients on the waitlist either died or became too sick for transplant.2 Wait times remain unacceptably high for heart transplant candidates. As a result, there has been growing interest in the development of innovative strategies to mitigate the donor organ shortage. During the past decade, the opioid epidemic in the United States has led to a dramatic increase in the number of organ donors who died as a result of drug intoxication.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Invited Expert Opinion Source Type: research

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Context: In the midst of the current opioid epidemic, states have selected differing legislative routes implementing pathways to ensure access to clean needles and syringes. Objective: To determine whether states that implemented laws supporting syringe exchange programs (SEPs) had reductions in transmission rates of hepatitis B, hepatitis C, and HIV infection compared with states without such laws. Design and Setting: Utilizing a longitudinal panel design, we determined the legal status of SEPs in each state for years 1983-2016. Disease transmission rates for this period were estimated via a simple Poisson regress...
Source: Journal of Public Health Management and Practice - Category: Health Management Tags: Research Reports: Research Full Report Source Type: research
Hepatitis C virus is a global public health threat, affecting 71 million people worldwide. Increasing recognition of the impact of this epidemic and recent advances in biomedical and technical approaches to hepatitis C prevention and cure have provided impetus for the World Health Organization (WHO) to call for global elimination of hepatitis C as a public health threat by 2030. This work reviews the feasibility of hepatitis C elimination and pathways to overcome existing and potential future barriers to elimination. Drawing on cost-effectiveness modeling and providing examples of successful implementation efforts across t...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Hepatitis C Viruses: The Story of a Scientific and Therapeutic Revolution PERSPECTIVES Source Type: research
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Source: AIDS Care - Category: Infectious Diseases Authors: Source Type: research
ODP 2020 Early-Stage Investigator Lecture Daily oral HIV pre-exposure prophylaxis, or PrEP, is up to 99% effective in preventing HIV transmission and has been approved by the Food and Drug Administration since 2012. However, of the 1.2 million Americans who could benefit from PrEP, less than 20% have used it, and there are substantial racial and ethnic disparities in uptake. Scale-up of PrEP is a critical component of the federal initiative to end the HIV epidemic, but achieving this goal will require effective strategies to improve PrEP implementation. In this presentation, Dr. Marcus will discuss her research on strategi...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
ConclusionsFewer than 20% of individuals with identified OUD were tested for HCV. SVR was lower than findings in other real-world cohorts. Measures to improve outcomes should be considered with the expansion of HCV management into community clinics.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
The development of multiple highly effective and safe direct-acting antivirals to treat hepatitis C virus (HCV) has resulted in greater ease and confidence in managing HCV infection in transplant recipients that in turn has impacted the solid organ transplant community as well. In the United States, the opioid epidemic has increased the number of overdose deaths with a concomitant increase in younger HCV viremic donors after brain death being identified. At the same time, a decrease in HCV viremic transplant candidates has led to a growing interest in exploring the use of HCV viremic liver and kidney donor allografts in HC...
Source: Transplantation - Category: Transplant Surgery Tags: Reviews Source Type: research
ODP 2020 Early-Stage Investigator Lecture Daily oral HIV pre-exposure prophylaxis, or PrEP, is up to 99% effective in preventing HIV transmission and has been approved by the Food and Drug Administration (FDA) since 2012. However, of the 1.2 million Americans who could benefit from PrEP, less than 20% have used it, and there are substantial racial and ethnic disparities in uptake. Scale-up of PrEP is a critical component of the federal initiative to end the HIV epidemic, but achieving this goal will require effective strategies to improve PrEP implementation. In this presentation, Dr. Marcus will discuss her research on st...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
CONCLUSION: When supported by a complex intervention, primary care can play a crucial role in identifying and caring for patients with HCV infection, to help stem the HCV epidemic, and prevent HCV-related illness. PMID: 32094220 [PubMed - as supplied by publisher]
Source: The British Journal of General Practice - Category: Primary Care Authors: Tags: Br J Gen Pract Source Type: research
Publication date: Available online 22 February 2020Source: Preventive MedicineAuthor(s): Nasser Sharareh, Rachel Hess, Scott White, Angela Dunn, Phillip M. Singer, Jerry CochranAbstractAfter the 2014–2015 HIV outbreak in Scott County, Indiana, United States Centers for Disease Control and Prevention (CDC) conducted a nationwide analysis to identify vulnerable counties to an outbreak of Hepatitis C Virus (HCV)/Human Immunodeficiency Virus (HIV) and prevent such an outbreak in the future. We developed a jurisdiction-level vulnerability assessment for HCV infections associated with injection drug use (IDU) in Utah.We us...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
The opioid epidemic in the U.S. is driving a simultaneous epidemic of infectious diseases— including HIV, hepatitis C virus (HCV) and bacterial infections, and sexually transmitted infections— but workforce shortages, stigma, and administrative burdens are preventing the integration of opioid use disorder (OUD) and infectious disease services, says a new report from the National Academies of Sciences, Engineering, and Medicine. It recommends a number of state and federal policy actions to address those barriers, including removing insurance requirements on prescribing medications for OUD (i.e., buprenorphine), ...
Source: News from the National Academies - Category: Science Source Type: news
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