Atherosclerotic cardiovascular disease in women with endometriosis: a systematic review of risk factors and prospects for early surveillance

Publication date: Available online 8 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Justin Tan, Omur Taskin, Mahmoud Iews, Arthur J Lee, Arohumam Kan, Timothy Rowe, Mohamed A BedaiwyAbstractEndometriosis and atherosclerotic cardiovascular disease (ASCVD) share similar pathogenic mechanisms. Hence, this systematic review evaluates the association between endometriosis and lifetime ASCVD risk including co-prevalence with dyslipidaemia, atherosclerosis and non-invasive markers of endothelial dysfunction. The electronic databases Embase, PubMed, MEDLINE, Cochrane Register of Trials and ClinicalTrials.gov were systematically searched for relevant articles. Two prospective cohort studies demonstrated an increased lifetime ASCVD risk after controlling for demographic and lifestyle confounders in women with endometriosis, as measured by higher incidence of myocardial infarction (relative risk [RR] 1.52), angiography-confirmed angina (RR 1.91), or requiring coronary artery bypass graft surgery (RR 1.35). Among 10 studies that included 407 patients with surgically proven endometriosis and 557 controls, RR of developing hypercholesterolemia and hypertension were 1.25 and 1.14, respectively, while higher serum lipoprotein a and lower paraoxonase 1 levels were found in women with endometriosis that was negatively correlated with stage of disease (r = −0.74, P 
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
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Publication date: Available online 8 June 2019Source: Reproductive BioMedicine OnlineAuthor(s): Justin Tan, Omur Taskin, Mahmoud Iews, Arthur J Lee, Arohumam Kan, Timothy Rowe, Mohamed A. BedaiwyABSTRACTEndometriosis and atherosclerotic cardiovascular disease (ASCVD) share similar pathogenic mechanisms. Hence, this systematic review evaluates the association between endometriosis and lifetime ASCVD risk including co-prevalence with dyslipidemia, atherosclerosis, and non-invasive markers of endothelial dysfunction. Among 12 studies (401 patients with surgically proven endometriosis and 557 controls), two prospective-cohort ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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