IJERPH, Vol. 16, Pages 3732: Toxoplasma gondii Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish
IJERPH, Vol. 16, Pages 3732: Toxoplasma gondii Serointensity and Seropositivity: Heritability and Household-Related Associations in the Old Order Amish
International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16193732
Authors:
Allyson R. Duffy
Jeffrey R. O’Connell
Mary Pavlovich
Kathleen A. Ryan
Christopher A. Lowry
Melanie Daue
Uttam K. Raheja
Lisa A. Brenner
André O. Markon
Cecile M. Punzalan
Aline Dagdag
Dolores E. Hill
Toni I. Pollin
Andreas Seyfang
Maureen W. Groer
Braxton D. Mitchell
Teodor T. Postolache
Toxoplasma gondii (T. gondii) is an intracellular parasite infecting one third of the world’s population. Latent T. gondii infection has been associated with mental illness, including schizophrenia and suicidal behavior. T. gondii IgG antibody titers were measured via ELISA. The heritability of T. gondii IgG was estimated using a mixed model that included fixed effects for age and sex and random kinship effect. Of 2017 Old Order Amish participants, 1098 had positive titers (54.4%). The heritability for T. gondii serointensity was estimated to be 0.22 (p = 1.7 × 10−8 and for seropositivity, it was estimated to be 0.28 (p = 1.9 × 10−5). Shared household environmental effects (i.e., household effects) were also determined. Household effects, modeled as a random variable, were assessed as the phenotypic covariance between any two indiv...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Allyson R. Duffy Jeffrey R. O ’Connell Mary Pavlovich Kathleen A. Ryan Christopher A. Lowry Melanie Daue Uttam K. Raheja Lisa A. Brenner Andr é O. Markon Cecile M. Punzalan Aline Dagdag Dolores E. Hill Toni I. Pollin Andreas Seyfang Maureen W. Groer Br Tags: Article Source Type: research
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