Inflammation in tuberculosis: interactions, imbalances and interventions.

Inflammation in tuberculosis: interactions, imbalances and interventions. Curr Opin Immunol. 2013 May 28; Authors: Kaufmann SH, Dorhoi A Abstract Inflammation is critical for tuberculosis (TB) pathogenesis. The nonresolving aspect of inflammation in TB is caused by sophisticated intracellular survival strategies of tubercle bacilli. TB is a continuum comprising a spectrum of lesions as a consequence of complex regulation of inflammation. Proinflammatory cytokines, including interferons, tumor necrosis factor and interleukin 1 along with microRNAs and eicosanoids form an interactive network during TB. Cross-regulation between proinflammatory mediators strongly impacts on infected cell death patterns. These processes, in concert with local concentrations of proteases, such as cathepsins, serpins and matrix-metalloproteinases, affect tissue integrity, shape the architecture of granulomas and modulate tissue repair. With inflammation networks being uncovered in TB, the relevance of several pathways for novel interventions becomes clearer. PMID: 23725875 [PubMed - as supplied by publisher]
Source: Current Opinion in Immunology - Category: Allergy & Immunology Authors: Tags: Curr Opin Immunol Source Type: research

Related Links:

This study provides strong evidence that following a healthy lifestyle can substantially extend the years a person lives disease-free." Commentary on Recent Evidence for Cognitive Decline to Precede Amyloid Aggregation in Alzheimer's Disease https://www.fightaging.org/archives/2020/01/commentary-on-recent-evidence-for-cognitive-decline-to-precede-amyloid-aggregation-in-alzheimers-disease/ I can't say that I think the data presented in the research noted here merits quite the degree of the attention that it has been given in the popular science press. It is interesting, but not compelling if its role...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Tuberculosis (TB) is one such disease that has become a nuisance in world scenario and one of the most deadly diseases of current times. The etiological agent of tuberculosis, Mycobacterium tuberculosis (Mtb) kills millions of people each year. Not only 1.7 million people worldwide are estimated to harbor Mtb in latent form but 5 to 15 percent of which are expected to acquire an infection during lifetime. Though curable, long duration of drug regimen and expense leads to low patient adherence. Emergence of multi-, extensive- and total- drug resistant strains of Mtb further complicates the situation. Owing...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Abstract The UvrB subunit is a central component of the UvrABC incision complex and plays a pivotal role in damage recognition, strand excision and repair synthesis. A conserved structural motif (the SxSx motif) present in UvrB is analogous to a similar motif (TxGx) in the helicases of superfamily 2, whose function is not fully understood. To elucidate the significance of the SxSx (Ser143-Val144-Ser145-Cys146) motif in Mycobacterium tuberculosis UvrB (MtUvrB), different variants of MtUvrB subunit were constructed and characterized. The SxSx motif indeed was found to be essential for MtUvrB function: while Ser143 a...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research
The UvrABC excinuclease plays a vital role in bacterial nucleotide excision repair. While UvrA and UvrB subunits associate to form a UvrA2B2 complex, interaction between UvrA and UvrC has not been demonstrated or quantified in any bacterial species. Here, usingMycobacterium  tuberculosis UvrA (MtUvrA), UvrB (MtUvrB) and UvrC (MtUvrC) subunits, we show that MtUvrA binds to MtUvrB and equally well to MtUvrC with submicromolar affinity. Furthermore, MtUvrA forms a complex with MtUvrC bothin  vivo andin  vitro, independently of DNA and UvrB. Collectively, these findings reveal new insights into the pairwise rela...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: Research Article Source Type: research
Nitric oxide (NO) is a marker of endothelial dysfunction and nitrosative stress involved in the COPD pathogenesis. The aim is to assess the role of NO in COPD pathogenesis in pulmonary tuberculosis (PT) patients.Methods: In 47 male smokers: 28 PT (1st group) and 19 patients with PT and COPD (2nd group), the pulmonary function testing and the concentration of nitrite (NO2 -), nitrate (NO3-) in serum (s), mononuclear cells (mn) and neutrophils (nf) of blood ELISA- kit were assessed.Results: In both groups, a decrease in the level of NO3-s (Me-9.4 and 14.2 mmol / l, p
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Mechanisms of lung injury and repair Source Type: research
AbstractThe UvrABC excinuclease plays a vital role in bacterial nucleotide excision repair. While UvrA and UvrB subunits associate to form a UvrA2B2 complex, interaction between UvrA and UvrC has not been demonstrated or quantified in any bacterial species. Here, usingMycobacterium tuberculosis UvrA (MtUvrA), UvrB (MtUvrB) and UvrC (MtUvrC) subunits, we show that MtUvrA binds to MtUvrB and equally well to MtUvrC with submicromolar affinity. Furthermore, MtUvrA forms a complex with MtUvrC bothin vivo andin vitro, independently of DNA and UvrB. Collectively, these findings reveal new insights into the pair ‐wise relationsh...
Source: FEBS Letters - Category: Biochemistry Authors: Tags: RESEARCH ARTICLE Source Type: research
In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Itaconate is an immunometabolite with both anti-inflammatory and bactericidal effects. Its coenzyme A (CoA) derivative, itaconyl-CoA, inhibits B12-dependent methylmalonyl-CoA mutase (MCM) by an unknown mechanism. We demonstrate that itaconyl-CoA is a suicide inactivator of human and Mycobacterium tuberculosis MCM, which forms a markedly air-stable biradical adduct with the 5'-deoxyadenosyl moiety of the B12 coenzyme. Termination of the catalytic cycle in this way impairs communication between MCM and its auxiliary repair proteins. Crystallography and spectroscopy of the inhibited enzyme are consistent with a metal-centered...
Source: ScienceNOW - Category: Science Authors: Tags: Biochemistry r-articles Source Type: news
This study provides a further understanding of Cas1 in Mycobacterium tuberculosis complex (MTBC) drug-resistance evolution and a new sight for the tuberculosis treatment. PMID: 31061828 [PubMed - indexed for MEDLINE]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Mycobacterium tuberculosis (M. tb) is one of most pathogenic microorganism in the world. It was reported that M. tb GlmU was a potential drug target, therefore, discovering compounds targeting GlmU acetyltransferase is necessary. The nature-driven compounds were tested for inhibiting GlmU acetyltransferase activity. It was found that dicumarol exhibited inhibitory effect on GlmU acetyltransferase with the IC50 value of 4.608 μg/ml (13.7 μM). The inhibition kinetics indicated that dicumarol displayed an uncompetitive inhibition for acetyl CoA and noncompetition-competition mixed type inhibition for GlcN-1-P, respectiv...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
More News: Allergy & Immunology | Gastroschisis Repair | Tuberculosis