Activation of The Metabolic Master Regulator PPAR γ - A Potential PIOneering Therapy for Pulmonary Arterial Hypertension.
The objective is a data-driven approach to set the preclinical and clinical study record straight. The convincing recent clinical trial data on the lack of significant toxicity in high risk populations justify the timely conduction of clinical studies in order to achieve "repurposing" or "repositioning" of pioglitazone for the treatment of clinical PAH. PMID: 31577451 [PubMed - as supplied by publisher]
ConclusionsE-cigarette use should be assessed and monitored to understand the safety and potential efficacy of e-cigarettes as a harm reduction approach for HF patients.
Condition: Gestational Diabetes Interventions: Other: Meal A; Other: Meal B Sponsor: Massachusetts General Hospital Not yet recruiting
Conditions: Diabetic Macular Edema; Macular Edema; Type 2 Diabetes With Diabetic Macular Edema; Type 1 Diabetes With Diabetic Macular Edema; Diabetic Retinopathy Intervention: Drug: MS-553 Sponsors: Shenzhen MingSight Relin Pharmaceuticals Co., Ltd.; Fountain Medical Development Co., Ltd. Not yet recruiting
Conditions: Stroke; Stroke, Acute; Stroke, Subacute; Robotics Intervention: Device: Use of the Atalante exoskeleton Sponsor: Wandercraft Recruiting
Condition: Stroke Intervention: Behavioral: augmented reality Sponsors: University of Pittsburgh; Northeastern University; NSF Not yet recruiting
Condition: Diabetes Mellitus, With Complications Intervention: Procedure: INTRAVITREAL RANIBIZUMAB INJECTION Sponsor: Ain Shams University Completed
Conditions: Stroke Sequelae; Brain Ischemia Intervention: Other: EEG -BCI based Feedback for rehabilitation Sponsor: University of Houston Recruiting
Limiting food consumption to a 10-hour window a day, so-called time-restricted eating, promotes weight loss and improves lipids/blood pressure in patients with metabolic syndrome.Medscape Medical News
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
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