Current study of the detection and treatment targets of spinal tuberculosis.

Current study of the detection and treatment targets of spinal tuberculosis. Curr Drug Targets. 2019 Oct 02;: Authors: Wang B, Gao W, Hao D Abstract Spinal tuberculosis is a common manifestation of extrapulmonary tuberculosis and osteoarticular tuberculosis. Common clinical manifestations include constitutional symptoms, back pain, spinal tenderness, paraplegia, and spinal deformities. They are the common causes of paralysis and have a great impact on the patients. Most cases of spinal tuberculosis are concealed, and early clinical symptoms and imaging manifestations lack specificity, which is difficult to identify from atypical spinal metastases, brucellosis and other diseases. The rate of missed diagnosis and misdiagnosis for spinal tuberculosis is high. If spinal tuberculosis diagnositic targets could be early detected, as well as the therapeutic targets then can be effectively treated, which can not only control the progress of the disease and shorten the course of treatment, but also reduce economic pressure and avoid the occurrence of spinal deformity. Therefore, early diagnosis should be our focus. Comprehensive use of a variety of diagnostic targets can improve the early diagnosis rate of spinal tuberculosis. Here, we review the progress of laboratory, imaging and gene detection in diagnosis of spinal tuberculosis in the recent years. PMID: 31577205 [PubMed - as supplied by publisher]
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research