Unbiased Proteomics Method to Assess the Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes.

Conclusions: We established an unbiased proteomics method that can provide accurate and specific assessment of the maturity of hPSC-CMs, and identified new markers of maturation. Furthermore, this integrated proteomics strategy laid a strong foundation for uncovering the molecular pathways involved in cardiac development and disease using hPSC-CMs.
PMID: 31573406 [PubMed - as supplied by publisher]

Source: Circulation Research - September 30, 2019 Category: Cardiology Authors: Cai W, Zhang J, De Lange WJ, Gregorich ZR, Karp H, Farrell ET, Mitchell ST, Tucholski T, Lin Z, Biermann M, McIlwain S, Ralphe JC, Kamp TJ, Ge Y Tags: Circ Res Source Type: research