CXCR4-targeted PET imaging using 64Cu-AMD3100 for detection of Waldenstr öm Macroglobulinemia.
Conclusions: In conclusion, we developed a molecularly targeted system, 64Cu-AMD3100, which binds to CXCR4 and specifically detects WM cells with hypoxic phenotype and metastatic potential in the subcutaneous and intratibial models. These preliminary findings using CXCR4-detecting PET radiopharmaceutical tracer indicate a potential technology to predict high-risk patients for the progression to WM due to metastatic potential.
PMID: 31571524 [PubMed - as supplied by publisher]
Source: Cancer Biology and Therapy - Category: Cancer & Oncology Authors: Muz B, Bandara N, Mpoy C, Sun J, Alhallak K, Azab F, Rogers BE, Azab AK Tags: Cancer Biol Ther Source Type: research
More News: Biology | Cancer | Cancer & Oncology | CT Scan | Macroglobulinemia | PET Scan | Waldenstrom's Macroglobulinemia