High sensitivity troponin assays: development and utility in a modern healthcare system.

This article reviews the history and development of high sensitivity troponin assays and their application to clinical practice and current evidence base. It also discusses both the positive and negative aspects of the continuing increasing sensitivity of biochemical assays and the translation of this into clinical practice. Potential future developments are also discussed. Expert commentary: It is clear that there are many benefits to detecting extremely low concentration of cardiac troponin including the development of rapid rule out algorithms and the cost and time saving advantages associated with the quicker movement of patients through the healthcare system. It is important to note however that detecting troponin at very low concentrations also dramatically increases the false positive rates and leads to a potentially large increase in invasive testing and diagnosis of myocardial infarction. PMID: 31574239 [PubMed - as supplied by publisher]
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research