Effects of 24 CYP2D6 variants found in Chinese population on the metabolism of clonidine in vitro

ConclusionWe comprehensively evaluated the effect of 22 novel CYP2D6 variants on the metabolism of clonidine for the first time and hoped corresponding data provide a reference for metabolism of clonidine for further studies in vivo, and extend our understanding of the clinical drug toxicity or ineffectiveness by CYP2D6 genetic polymorphism.
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research