Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology.

Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology.
Comb Chem High Throughput Screen. 2019;22(6):411-420
Authors: Wu XJ, Zhou XB, Chen C, Mao W
Abstract
AIM AND OBJECTIVE: Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a significant effect on the treatment of cardiovascular diseases. However, its precise mechanism is still unclear. Therefore, it is necessary to exploit the network pharmacological potential effects of quercetin on cardiovascular disease.
MATERIALS AND METHODS: In the present study, a novel network pharmacology strategy based on pharmacokinetic filtering, target fishing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, compound-target-pathway network structured was performed to explore the anti- cardiovascular disease mechanism of quercetin.
RESULTS: The outcomes showed that quercetin possesses favorable pharmacokinetic profiles, which have interactions with 47 cardiovascular disease-related targets and 12 KEGG signaling pathways to provide potential synergistic the...

Source: Combinatorial Chemistry and High Throughput Screening - October 2, 2019 Category: Chemistry Authors: Wu XJ, Zhou XB, Chen C, Mao W Tags: Comb Chem High Throughput Screen Source Type: research