Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology.

Systematic Investigation of Quercetin for Treating Cardiovascular Disease Based on Network Pharmacology. Comb Chem High Throughput Screen. 2019;22(6):411-420 Authors: Wu XJ, Zhou XB, Chen C, Mao W Abstract AIM AND OBJECTIVE: Cardiovascular disease is a serious threat to human health because of its high mortality and morbidity rates. At present, there is no effective treatment. In Southeast Asia, traditional Chinese medicine is widely used in the treatment of cardiovascular diseases. Quercetin is a flavonoid extract of Ginkgo biloba leaves. Basic experiments and clinical studies have shown that quercetin has a significant effect on the treatment of cardiovascular diseases. However, its precise mechanism is still unclear. Therefore, it is necessary to exploit the network pharmacological potential effects of quercetin on cardiovascular disease. MATERIALS AND METHODS: In the present study, a novel network pharmacology strategy based on pharmacokinetic filtering, target fishing, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, compound-target-pathway network structured was performed to explore the anti- cardiovascular disease mechanism of quercetin. RESULTS: The outcomes showed that quercetin possesses favorable pharmacokinetic profiles, which have interactions with 47 cardiovascular disease-related targets and 12 KEGG signaling pathways to provide potential synergistic therapeutic effects. Following...
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research

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Authors: LeBlanc AG, Jun Gao Y, McRae L, Pelletier C Abstract In 1999, the Government of Canada, along with the provinces and territories, established the National Diabetes Surveillance System (NDSS) to track rates of diabetes in Canada. The NDSS used a novel method to systematically collect and report national diabetes data using linked administrative health databases. The NDSS has since evolved to become the Canadian Chronic Disease Surveillance System (CCDSS) and provides information on over 20 chronic conditions. This At-a-glance report provides the most up-to-date CCDSS information on diabetes rates in Canada....
Source: Health Promotion and Chronic Disease Prevention in Canada - Category: International Medicine & Public Health Tags: Health Promot Chronic Dis Prev Can Source Type: research
Authors: Nikolajczyk BS, Dawson DR Abstract New strategies are critically needed to counter uncontrolled periodontal infection and inflammation in obesity-associated type 2 diabetes (T2D). However, mechanisms that explain the relationship between periodontitis (PD) and T2D remain poorly understood. Several lines of evidence indicate that destructive immune responses potentiate periodontitis (PD) in T2D. B cells are abundant in periodontal lesions, and our data show that B cells are required for PD in obese/insulin resistant but not lean/normoglycemic mice. In mice and in people, T2D-primed B cells supported Th17 cy...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Medical and Biological Engineering and Computing - Category: Biomedical Engineering Source Type: research
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Source: BMC Proceedings - Category: Biomedical Science Source Type: research
BOSTON (CBS) — Many middle-aged adults worry they will develop dementia but are turning to unproven strategies to reduce their risk. Looking at survey data on more than 1,000 middle-aged men and women, researchers at the University of Michigan found that nearly half believe they were at least somewhat likely to develop dementia. More than a third believed that taking supplements like fish oil and vitamin E could help prevent dementia, despite the fact that the latest research does not support those claims. Only 5 percent had discussed ways to prevent dementia, like controlling high blood pressure or diabetes and...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Dementia Dr. Mallika Marshall Source Type: news
CONCLUSIONS: This retrospective study further supports previous evidence that acellular fish skin graft promotes wound healing in DFUs. In particular, a rapid increase in wound healing was observed during the initial 4 weeks following graft application. This study and review of the literature indicated that fish graft encourages wound healing by enabling the wound to transition from a chronic to an acute stage of healing. PMID: 31730505 [PubMed - as supplied by publisher]
Source: Wounds - Category: General Medicine Tags: Wounds Source Type: research
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Source: Diabetes Mine - Category: Endocrinology Authors: Source Type: blogs
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Source: Diabetologia - Category: Endocrinology Source Type: research
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