P.08Interferon level assessed by ultrasensitive detection technology in myositis patients: a promising biomarker of disease activity in dermatomyositis and anti-synthetase syndrome

Inflammatory idiopathic myopathies (IIM) are a heterogeneous group of disorders ranging from muscle specific auto-immune diseases to systemic ones (dermatomyositis (DM), anti-synthetase syndrome (ASyS), immune-mediated necrotizing myopathy (IMNM) and inclusion body myositis (IBM)). Recent insight into DM pathogenesis highlighted the role of type I interferon (IFN) and the level of IFN-pathway activity is linked to those of the disease. The aim of this study was to measure IFN- α, β and γ seric level in the different groups of myositis using an ultrasensitive detection technology to evaluate IFN-α as disease activity biomarker.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research