P.284Disordered brain connectivity and reduced grey matter volume in Duchenne muscular dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting condition caused by a lack of the protein dystrophin. Approximately 50% of patients also have central nervous system co-morbidities, such as intellectual disability (ID), autism, emotional and behavioural problems. The risk of ID, and possibly other disorders, increases when shorter forms of dystrophin transcribed in the CNS are also absent (Dp140/Dp71 isoforms). Previous brain magnetic resonance imaging (MRI) studies in DMD have shown smaller total brain and grey matter volume and altered corpus callosal white matter microstructure.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research