Mri – muscle imaging

The degree of fatty infiltration, as measured using water-fat NMR imaging separation techniques (such as Dixon) is now a widely accepted muscle imaging biomarker and an often proposed outcome measure in many neuromuscular disease longitudinal studies. The question remains which is the specific muscle (group) to evaluate during the study period. We aimed to compare different segmentation approaches (global vs individual muscles) in a variety of neuromuscular disorders: immune-mediated necrotizing myopathy (IMNM), inclusion body myositis (IBM), GNE myopathy (GNEM), Duchenne muscular dystrophy (DMD), limb-girdle muscular dystrophy types 2B and 2I, Pompe disease (GSD2) and spinal muscular atrophy (SMA).

Source: Neuromuscular Disorders - September 30, 2019 Category: Neurology Authors: H. Reyngoudt, J. Boisserie, J. Le Lou ër, C. Koumako, P. Baudin, B. Wong, T. Stojkovic, A. Behin, T. Gidaro, L. Servais, Y. Allenbach, O. Benveniste, B. Marty, P. Carlier Source Type: research