P.300Diaphragm imaging in Duchenne muscular dystrophy (DMD)

Reliable outcome measures able to demonstrate specific trends of disease progression are essential in this era of clinical trials in DMD. Magnetic resonance imaging (MRI) is increasingly being used to assess muscular degeneration in dystrophic patients. We studied muscle diaphragm through MRI and correlated MRI measurements of diaphragm structure and function with compartmental tidal volumes measured by opto-electronic plethysmography (OEP) and pulmonary function tests. 26 DMD patients and 12 age-matched controls were acquired in breath-hold on a 3T-scanner at full-expiration (EXP) and full-inspiration (INSP), by a multi-point gradient echo Dixon sequence.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research