P.318MRI evaluation of skeletal muscle in the deltaE50-MD dog model of Duchenne muscular dystrophy

There is currently no cure for the fatal X-linked disorder Duchenne muscular dystrophy (DMD) and clinically-applicable translational trials continue to rely heavily on use of animal models. The Royal Veterinary College has a unique colony of dystrophin deficient dogs: the deltaE50-MD dog model. Magnetic Resonance Imaging (MRI) is a valuable non-invasive technique for monitoring the progression of the disease in human DMD patients. The aim was to determine if the deltaE50-MD dog has a skeletal muscle MRI phenotype that resembles that of DMD boys and to determine MRI differences of skeletal muscles in dystrophic and wildtype dogs.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research