Publication of Cochrane Review: ‘Exercise therapy for chronic fatigue syndrome’

Today, Cochrane publishes an amended version of the Review,' Exercise therapy for chronic fatigue syndrome. ’ In the last nine months, this Cochrane Review has been modified by the review ’s authors and evaluated by independent peer reviewers and editors. It now places more emphasis on the limited applicability of the evidence to definitions of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) used in the included studies, the long-term effects of exercise on symptoms of fatigue, and acknowledges the limitations of the evidence about harms that may occur.Cochrane ’s Editor-in-Chief, Dr Karla Soares-Weiser, commented on the publication of the review, “Cochrane recognizes the importance of providing the best available evidence on interventions for ME/CFS to enable patients and clinicians across the world to make well-informed decisions about treatment. Thi s amended review is still based on a research question and a set of methods from 2002, and reflects evidence from studies that applied definitions of ME/CFS from the 1990s. Having heard different views expressed about the evidence base for this condition, we acknowledge that the publication of this amended review will not resolve all the ongoing questions about this globally important health topic.“We have decided, therefore, that a new approach to the publication of evidence in this area is needed; and, today we are committing to the production of a full update of this Cochrane Review,...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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ConclusionsThis is the first report about HERV-K differential expression in moderate ME/CFS. Although the relationship between HERVs and ME/CFS has yet to be proven, the observation of this phenomenon deserves further attention.
Source: Autoimmunity Highlights - Category: Allergy & Immunology Source Type: research
In 1983, a health professional in her 30s walked into my office and said, “I’ve been healthy all of my life. A year ago, I came down with some kind of virus — sore throat, aching muscles, swollen lymph glands, fever. My fatigue was so bad I was in bed for nearly a week. Many of the symptoms gradually improved, but the terrible fatigue and difficulty thinking have not gotten better. They’re so bad I can’t fulfill my responsibilities at home or at work. This illness is affecting my brain, stealing my energy, and affecting my immune system. It’s keeping me from realizing my dreams.” T...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Fatigue Health Source Type: blogs
ConclusionA consistent finding among all papers included in this review was impaired NK cell cytotoxicity, suggesting that it is a reliable and appropriate cellular model for continued research in ME/CFS patients. Aberrations in NK cell lytic protein levels were also reported. Although additional research is recommended, current research provides a foundation for subsequent investigations. It is possible that NK cell abnormalities can be used to characterise a subset of ME/CFS due to the heterogeneity of both the illness itself and findings between studies investigating specific features of NK function.
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Conditions:   Fatigue Syndrome, Chronic;   Microbial Colonization Interventions:   Procedure: Faecal transplantation;   Procedure: Placebo faecal transplantation Sponsors:   Tampere University Hospital;   Helsinki University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disease, whose exact cause remains unclear. A wide range of risk factors has been proposed that helps understanding potential disease pa...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
Conditions:   Psychological Adaptation;   Cognitive Change Intervention:   Behavioral: CBT-based group therapy for patients with chronic fatigue syndrome (CFS) Sponsor:   Joint Authority for Päijät-Häme Social and Health Care Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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